P82 REDUCTION IN ENDOTHELIAL, BUT NOT MICROVASCULAR, FUNCTION DURING ACUTE INFLAMMATION: PRELIMINARY RESULTS

DOI

10.1016/j.artres.2018.10.135How to use a DOI?

Abstract

Acute inflammation is associated with increased risk for cardiovascular events and leads to reductions in conduit artery (flow-mediated dilation, FMD) and resistance vessel endothelial function. Whether this dysfunction during acute inflammation is further transmitted down the arterial tree to the microvasculature, inhibiting its ability to dilate or be recruited in response to a hypoxic stimulus, has yet to be investigated. Microvascular function and reactivity can be non-invasively measured using near-infrared spectroscopy (NIRS) during and following an occlusive stimulus.

Purpose: To investigate whether acute inflammation impairs microvascular function.

Methods: The typhoid vaccine was used to induce acute systemic inflammation in 16 young, healthy adults (8 male, 26.3 ± 3.0 years; 21.7 ± 2.4 kg/m²). Blood pressure, FMD of the brachial artery, and NIRS of the forearm flexor muscles were measured at baseline and 24-h following the vaccination. NIRS was analyzed during a 5-min arterial occlusion to obtain markers of microvascular function and reactivity from the tissue saturation index (TSI): occlusion slope (muscle oxidative capacity); and reperfusion slope, reperfusion magnitude, and peak hyperemic response (microvascular reactivity).

Results: Mean arterial pressure did not change during the inflammatory episode (90 ± 9 mmHg to 90 ± 7 mmHg, p = 0.83) and FMD was significantly reduced at 24 h (5.6 ± 2.6% to 4.1 ± 1.7%, p = 0.03). No change was noted in the TSI occlusion slope, reperfusion slope, reperfusion magnitude, or peak hyperemic response (p > 0.05).

Conclusion: Vaccination-induced acute inflammation reduced endothelial function. However, no differences were noted in microvascular reactivity or oxidative capacity. Further investigation with a larger sample size is necessary to confirm these results.

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TY  - JOUR
AU  - Elizabeth Schroeder
AU  - Thessa Hilgenkamp
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2018
DA  - 2018/12/04
TI  - P82 REDUCTION IN ENDOTHELIAL, BUT NOT MICROVASCULAR, FUNCTION DURING ACUTE INFLAMMATION: PRELIMINARY RESULTS
JO  - Artery Research
SP  - 102
EP  - 102
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.135
DO  - 10.1016/j.artres.2018.10.135
ID  - Schroeder2018
ER  -