P90 KINETIC ENERGY AND ENERGY LOSS IN THE MIDDLE CEREBRAL ARTERY (MCA) OF HEARTMATE II PATIENTS

Koichi Akiyama; Ruiping Ji; Autumn Clemons; Francesco Castagna; Alberto Pinsino; John R. Cockcroft; Melana Yuzefpolsakaya; Reshad Garan; Hiroo Takayama; Koji Takeda; Yoshifumi Naka; Veli Topkara; Joshua Willey; Barry J. McDonnell; Paolo Colombo; Eric Stöhr

doi:10.1016/j.artres.2018.10.143

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Volume 24, Issue C, December 2018, Pages 104 - 105

P90 KINETIC ENERGY AND ENERGY LOSS IN THE MIDDLE CEREBRAL ARTERY (MCA) OF HEARTMATE II PATIENTS

Authors

Koichi Akiyama¹, Ruiping Ji¹, Autumn Clemons¹, Francesco Castagna¹, Alberto Pinsino¹, John R. Cockcroft², Melana Yuzefpolsakaya¹, Reshad Garan¹, Hiroo Takayama¹, Koji Takeda¹, Yoshifumi Naka¹, Veli Topkara¹, Joshua Willey¹, Barry J. McDonnell¹, Paolo Colombo¹, Eric Stöhr³

¹Columbia University, New York, USA

²Cardiff Metropolitan University, Cardiff, UK

³Columbia University, USA

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.143 How to use a DOI?
Abstract: Background: In heart failure patients with continuous-flow left ventricular assist devices (CF-LVAD), arterial pulsatility in the brain is reduced and diastolic blood velocities (Vmin) are maintained. The effects of such altered hemodynamics on kinetic energy and, importantly, energy loss in the cerebral circulation have never been studied.

Methods: Angle-corrected Doppler ultrasound movies of the middle cerebral artery (MCA) were recorded in 11 healthy volunteers, 5 patients with severe heart failure, and 4 patients with HM II. Data were analyzed offline using validated Vector Flow Mapping software (Cardio Flow Design, Tokyo, Japan). Vmin, pulsatility index (PI), total Energy Loss (ELAUC) and total Kinetic Energy (KEAUC) and both variables normalized for different heart rates (ELAUC/time & KEAUC/time) were calculated (Figure 1). Correlations between these energetic parameters and PI were determined.

Results: PI, KEAUC and ELAUC were significantly lower in HM II (P < 0.0001 and P < 0.05) while Vmin was similar (Fig 1). Normalization of data for different heart rates (ELAUC/time & KEAUC/time) revealed the same results. PI correlated with KEAUC (logr2 = 0.33, P = 0.008) but not ELAUC (logr2 = 0.154, P = 0.087).

Conclusions: ELAUC and KEAUC were significantly lower in HM II. The correlation between KEAUC and PI suggests that pulsatility may have an important impact not only on the stretch of arteries but also on the energetics of blood flow. Future studies should evaluate the clinical meaning of these observations.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 104 - 105
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.143 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Koichi Akiyama
AU  - Ruiping Ji
AU  - Autumn Clemons
AU  - Francesco Castagna
AU  - Alberto Pinsino
AU  - John R. Cockcroft
AU  - Melana Yuzefpolsakaya
AU  - Reshad Garan
AU  - Hiroo Takayama
AU  - Koji Takeda
AU  - Yoshifumi Naka
AU  - Veli Topkara
AU  - Joshua Willey
AU  - Barry J. McDonnell
AU  - Paolo Colombo
AU  - Eric Stöhr
PY  - 2018
DA  - 2018/12/04
TI  - P90 KINETIC ENERGY AND ENERGY LOSS IN THE MIDDLE CEREBRAL ARTERY (MCA) OF HEARTMATE II PATIENTS
JO  - Artery Research
SP  - 104
EP  - 105
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.143
DO  - 10.1016/j.artres.2018.10.143
ID  - Akiyama2018
ER  -

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