Artery Research

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Volume 24, Issue C, December 2018, Pages 98 - 98

P67 UNRELIABLE PULSE WAVE VELOCITY VALUES PROVIDED BY ALGORITHM-BASED DEVICE: A STUDY IN MARFAN SYNDROME

Authors
Giulia Furlanis1, Paolo Salvi2, Andrea Grillo3, Lucia Salvi4, Inês Pintassilgo5, Elisabetta Bungaro6, Raffaella Gaetano7, Susan Marelli8, Renzo Carretta1, Alessandro Pini8, Gianfranco Parati9, 2
1University of Trieste, Trieste, Italy
2IRCCS Istituto Auxologico Italiano, Milan, Italy
3University of Milano-Bicocca, Milano, Italy
4University of Pavia, Pavia, Italy
5Hospital Garcia de Orta, Almada, Portugal
6University of Milan, Milan, Italy
7IBIM CNR Istituto di Biomedicina e Immunologia Molecolare A, Morroy, Palermo, Italia
8Cardiologia, ASST Fatebenefratelli Sacco, Milan, Italy
9University of Milano-Bicocca, Milan, Italy
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.120How to use a DOI?
Abstract

Objective: To evaluate the reliability of algorithm-based aortic pulse wave velocity (PWV) estimated by the Mobil-O-Graph (IEM, Germany) compared to a standard non-invasive measurement of aortic PWV (carotid-femoral PWV), in a population of patients with a genetic disorder causing premature stiffening of the arterial wall: Marfan syndrome.Methods:In this study, 107 patients with confirmed Marfan syndrome were enrolled (mean age 37.7 ± 15.1 years, males 50.4%, blood pressure 117.8 ± 13.6/69.0 ± 8.8 mmHg). PWV estimated by Mobil-O-Graph (which uses an algorithm based mainly on age and pressure acquired by oscillometric method) was compared with carotid-femoral PWV measured by PulsePen tonometer (DiaTecne, Italy). For each method, two measurements were performed simultaneously, in a single session.

Results: Mean values of PWV (±SD) of Marfan patients were 6.1 ± 1.3 m/s by Mobil-O-Graph and 8.8 ± 3.1 m/s by carotid-femoral PWV, with a weak correlation between the two (r = 0.34). The average underestimation by the Mobil-O-Graph was −2.7 ± 5.7 m/s. The values provided by Mobil-O-Graph may be derived in this population from the age square and the brachial systolic pressure (r2=0.98) according to the formula:PWV = age2/1000 + 0.038 * systolic blood pressure.

Conclusions: The Mobil-O-Graph provides PWV values of an ideal subject for a given age and pressure, but may not be able to evaluate the cardiovascular risk expressed by aortic PWV in patients with specific alterations of aortic wall properties, as demonstrated in this population with Marfan syndrome. The use of algorithms for the evaluation of PWV should therefore be discouraged in special populations at high cardiovascular risk.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
98 - 98
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Giulia Furlanis
AU  - Paolo Salvi
AU  - Andrea Grillo
AU  - Lucia Salvi
AU  - Inês Pintassilgo
AU  - Elisabetta Bungaro
AU  - Raffaella Gaetano
AU  - Susan Marelli
AU  - Renzo Carretta
AU  - Alessandro Pini
AU  - Gianfranco Parati
PY  - 2018
DA  - 2018/12/04
TI  - P67 UNRELIABLE PULSE WAVE VELOCITY VALUES PROVIDED BY ALGORITHM-BASED DEVICE: A STUDY IN MARFAN SYNDROME
JO  - Artery Research
SP  - 98
EP  - 98
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.120
DO  - 10.1016/j.artres.2018.10.120
ID  - Furlanis2018
ER  -