Artery Research

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Volume 24, Issue C, December 2018, Pages 97 - 97

P63 MODIFICATION OF SYMPATHETIC TONE BY RENAL ARTERY DENERVATION CAUSES EARLY, SIGNIFICANT AND SUSTAINED ARTERIAL DE-STIFFENING

Authors
Andrius Berukstis, Gintare Neverauskaite-Piliponiene, Nerijus Misonis, Vytautas Juknevicius, Jurate Balsyte, Aleksandras Laucevicius
Vilnius University, Faculty of Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.116How to use a DOI?
Abstract

Objective: To examine whether Sympathetic Renal Denervation (RDN) might have an additive value for cardiovascular risk decline beyond lowering blood pressure.

Methods: 73 selected patients with resistant hypertension had RDN performed. Arterial stiffness was measured, using applanation tonometry, before the procedure, 24 to 48 hours following the procedure and subsequently 1, 3 and 6 months after the RDN.

Results: Within 48 hours RDN significantly reduced carotid-femoral aortic pulse wave velocity (AoPWV) from 11.3 ± 2.7 to 10.3 ± 2.6 m/s (p = 0.001), the reduction was sustained at months 1, 3, and 6. Early changes of AoPWV value did not correlate with office systolic or diastolic BP (p = 0.45; p = 0.33). Furthermore, the higher the initial AoPWV value, the greater the reduction of AoPWV was observed after 6 months: Q1 8.4 ± 1, Δ 0.05 ± 1.6/Q2 10.1 ± 0.4, Δ 1.1 ± 1.4/Q3 12.2±0.8, Δ 1.8 ± 1.7/Q4 15.3 ± 1.7, Δ 2.8 ± 2.1, (p = 0.002).

Conclusion: A sustainable effect on AoPWV, observed in our study as early as within 24-48 hours following the procedure and up to 6 months, suggests an additional RDN effect on reducing arterial stiffness and cardiovascular risk. The de-stiffening effect was greater in patients with high initial AoPWV.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
97 - 97
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.116How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Andrius Berukstis
AU  - Gintare Neverauskaite-Piliponiene
AU  - Nerijus Misonis
AU  - Vytautas Juknevicius
AU  - Jurate Balsyte
AU  - Aleksandras Laucevicius
PY  - 2018
DA  - 2018/12/04
TI  - P63 MODIFICATION OF SYMPATHETIC TONE BY RENAL ARTERY DENERVATION CAUSES EARLY, SIGNIFICANT AND SUSTAINED ARTERIAL DE-STIFFENING
JO  - Artery Research
SP  - 97
EP  - 97
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.116
DO  - 10.1016/j.artres.2018.10.116
ID  - Berukstis2018
ER  -