P43 MASKED HYPERTENSION AND RETINAL VESSEL STRUCTURE AND FUNCTION IN YOUNG HEALTHY ADULTS: THE AFRICAN-PREDICT STUDY

Nthai Ramoshaba; Hugo Huisman; Leandi Lammertyn; Konstantin Kotliar; Aletta Schutte; Wayne Smith

doi:10.1016/j.artres.2018.10.096

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Volume 24, Issue C, December 2018, Pages 90 - 91

P43 MASKED HYPERTENSION AND RETINAL VESSEL STRUCTURE AND FUNCTION IN YOUNG HEALTHY ADULTS: THE AFRICAN-PREDICT STUDY

Authors

Nthai Ramoshaba¹, Hugo Huisman¹^{, 2}, Leandi Lammertyn¹^{, 2}, Konstantin Kotliar³, Aletta Schutte¹^{, 2}, Wayne Smith¹^{, 2}

¹Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa

²South African Medical Research Council, Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa

³Department of Biomedical Engineering and Technomathematics, Aachen University of Applied Sciences, Juelich, Germany

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.096 How to use a DOI?
Abstract: Background: Masked hypertension (MH) is prevalent in young adults and is associated with similar vascular complications as sustained hypertension, but whether this is already evident in young adults is unclear. We therefore compared retinal vessel calibres and function in response to flicker light induced provocation (FLIP) in young healthy adults stratified by MH status and explored associations between these parameters.

Methods: We used data from the first 566 participants (aged 20–30 years) taking part in the African-PREDICT study. Participants were clinically normotensive (70% valid readings) were measured and MH status determined. The central retinal artery (CRAE) and vein equivalent (CRVE) were calculated from fundus images and retinal vessel dilation responses to FLIP determined.

Results: MH showed a prevalence of 16%. MHs’ had a lower CRAE (155 ± 10 MU vs. 160 ± 12 MU, p = 0.002), but similar CRVE and vessel dilation in response to FLIP when compared to normotensives. The latter findings remained consistent upon adjustment for sex, ethnicity, age and body mass index. Multivariate regression analysis demonstrated an independent association between CRAE and the presence of MH (R2 = 0.07, β = −0.10 (−0.20; −0.01)). No further associations existed between retinal vessel parameters and MH status.

Conclusion: Already at a young age, healthy adults with MH show slight adverse changes in the retinal microvasculature. Considering the prevalence of MH in young adults, and the predictive value of reduced CRAE, our data emphasize the early identification of altered 24 hr blood pressure patterns.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 90 - 91
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.096 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Nthai Ramoshaba
AU  - Hugo Huisman
AU  - Leandi Lammertyn
AU  - Konstantin Kotliar
AU  - Aletta Schutte
AU  - Wayne Smith
PY  - 2018
DA  - 2018/12/04
TI  - P43 MASKED HYPERTENSION AND RETINAL VESSEL STRUCTURE AND FUNCTION IN YOUNG HEALTHY ADULTS: THE AFRICAN-PREDICT STUDY
JO  - Artery Research
SP  - 90
EP  - 91
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.096
DO  - 10.1016/j.artres.2018.10.096
ID  - Ramoshaba2018
ER  -

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