P56 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH RETINAL ARTERIOLAR WALL THICKNESS AND WALL CROSS SECTIONAL AREA AS EVALUATED BY ADAPTIVE OPTICS

Antonio Gallo; Thomas Dietenbeck; Nadjia Kachenoura; Valérie Carreau; Michel Paques; Xavier Girerd

doi:10.1016/j.artres.2018.10.109

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Volume 24, Issue C, December 2018, Pages 94 - 95

P56 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH RETINAL ARTERIOLAR WALL THICKNESS AND WALL CROSS SECTIONAL AREA AS EVALUATED BY ADAPTIVE OPTICS

Authors

Antonio Gallo¹^{, 2}, Thomas Dietenbeck², Nadjia Kachenoura², Valérie Carreau³, Michel Paques⁴, Xavier Girerd³

¹Cardiovascular Prevention Unit, University Hospital Pitié-Salpêtrière, Paris, France

²Sorbonne Université, INSERM, Laboratoire d’Imagerie Biomédicale, Paris, France

³Cardiovascular Prevention Unit, University Hospital Pitié-Salpêtrière, Paris, France

⁴Institut de la vision - Centre d’Investigation Clinique 503 Centre Hospitalier National des Quinze-Vingts, Assistance Publique-Hôpitaux de Paris, Paris, France

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.109 How to use a DOI?
Abstract: Introduction: In 1991 Baumbach et al demonstrated taht pulse pressure (PP) but not mean arterial pressure (MAP) was correlated with pial arterioles wall cross-sectional area (WCSA)in rats. Adaptive optics (AO) allows a near-histological evaluation of retinal microcirculation (which shares the same embryological origins as the cerebral one) in a completely non-invasive fashion in humans. The aim of the study was to evaluate the relationship between PP/MAP and retinal arteriolar microcirculation.

Methods: Assessment included office BP measurements realized with SphygmoCor^® with the patient resting in a supine position for at least 5 minutes followed by retinal microvascular analysis with AO RTX1^® Camera to measure WT, internal diameter (ID), wall-to-lumen ratio (WLR) and WCSA, realized with the patients sitting in a stable position for at least 5 minutes.

Results: The study cohort consisted of 103 subjects on primary prevention and at intermediate risk, aged 20 to 80 years, with arterial hypertension and/or dyslipidemia. Study population was stratified according to median central PP (40 mmHg) and MAP (94 mmHg). Main results are shown in Table 1. Patients with a higher central PP showed an increased WT and WCSA. No difference was observed in WT and WCSA according to MAP.

Conclusions: Central PP is associated with structural changes in retinal microcirculation, namely a wall thickening and an increased vascular mass, as previously found on cerebral arterioles. Adaptive Optics allows a non-invasive evaluation of a microvascular territory which shares many morphological and physiological properties with the cerebral microcirculation, representing a promising tool for the prevention of cerebrovascular events.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 94 - 95
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.109 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Antonio Gallo
AU  - Thomas Dietenbeck
AU  - Nadjia Kachenoura
AU  - Valérie Carreau
AU  - Michel Paques
AU  - Xavier Girerd
PY  - 2018
DA  - 2018/12/04
TI  - P56 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH RETINAL ARTERIOLAR WALL THICKNESS AND WALL CROSS SECTIONAL AREA AS EVALUATED BY ADAPTIVE OPTICS
JO  - Artery Research
SP  - 94
EP  - 95
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.109
DO  - 10.1016/j.artres.2018.10.109
ID  - Gallo2018
ER  -

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