P30 A 12-WEEK EXERCISE TRAINING PROGRAM REDUCES ENDOTHELIAL DAMAGE IN RESISTANT HYPERTENSION

Susana Lopes; Catarina Garcia; Ana Gonçalves; Ilda Ribeiro; Joana Barbosa de MElo; Veronica Ribau; Daniela Figueiredo; João Viana; Susana Bertoquini; Jorge Polónia; José Mesquita-Bsstos; Alberto Alves; Fernando Ribeiro

doi:10.1016/j.artres.2018.10.083

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Volume 24, Issue C, December 2018, Pages 88 - 88

P30 A 12-WEEK EXERCISE TRAINING PROGRAM REDUCES ENDOTHELIAL DAMAGE IN RESISTANT HYPERTENSION

Authors

Susana Lopes¹, Catarina Garcia¹, Ana Gonçalves², Ilda Ribeiro³, Joana Barbosa de MElo³, Veronica Ribau⁴, Daniela Figueiredo⁵, João Viana⁶, Susana Bertoquini⁷, Jorge Polónia⁸, José Mesquita-Bsstos⁴, Alberto Alves⁹, Fernando Ribeiro¹

¹School of Health Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal

²Center of Investigation on Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Center for Neuroscience and Cell Biology and Institute for Biomedical Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal

³Center of Investigation on Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, POrtugal

⁴Cardiology Department, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal

⁵School of Health Sciences and CINTESIS@UA, University of Aveiro, Aveiro, Portugal

⁶Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, Maia, Portugal

⁷Faculty of Medicine, University of Porto & Hypertension Unit, ULS Matosinhos, Porto, Portugal

⁸Faculty of Medicine, University of Porto & Hypertension Unit, ULS Matosinhos, Porto, Portugal

⁹Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, Maia, Portugal

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.083 How to use a DOI?
Abstract: Background: Resistant Hypertension (RH) is associated with an increased risk of cardiovascular events and poor prognosis. Exercise training studies in RH patients have shown promising outcomes, nonetheless, none determine the impact of exercise on endothelial damage and repair. Circulating endothelial cells (CECs) are a reliable indicator of vascular damage and dysfunction. Recent studies in hypertension suggest that increased levels of endothelial progenitor cells (EPCs), a marker of endothelial repair, are related to increased CECs in order to compensate endothelial damage. Purpose: This study aimed to determine the effect of 12-week aerobic exercise program on the percentage of EPCs and CECs in RH patients.

Methods: Patients with RH were randomized to a 12-week aerobic exercise program (3 xs/week) (n = 13) and a usual care control group (n = 8). Outcome measures included clinical data, ambulatory blood pressure data and circulating levels of EPCs, hematopoietic stem cells (HSC) and CECs, quantified by flow cytometry. (ClinicalTrials.gov: NCT03090529).

Results: Baseline characteristics were similar between groups, including the number of antihypertensive drugs (5.0 ± 0.9 vs. 4.8 ± 0.7, p = 0.517). After 12 weeks, no significant changes were found in the levels of HSCs in both groups. The levels of CECs decreased in the exercise group [0.0073 (0.0016)% to 0.0058 (0.0029), p = 0.019]; no changes were observed in the control group. EPC’s decreased only in the exercise group [0.0071 (0.0027)% to 0.0052 (0.0037)%, p = 0.046].

Conclusions: Exercise training reduces endothelial injury/damage (reduced CECs levels) in RH patients, a specific group who is a challenge for clinicians as the available treatment options have reduced success.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 88 - 88
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.083 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Susana Lopes
AU  - Catarina Garcia
AU  - Ana Gonçalves
AU  - Ilda Ribeiro
AU  - Joana Barbosa de MElo
AU  - Veronica Ribau
AU  - Daniela Figueiredo
AU  - João Viana
AU  - Susana Bertoquini
AU  - Jorge Polónia
AU  - José Mesquita-Bsstos
AU  - Alberto Alves
AU  - Fernando Ribeiro
PY  - 2018
DA  - 2018/12/04
TI  - P30 A 12-WEEK EXERCISE TRAINING PROGRAM REDUCES ENDOTHELIAL DAMAGE IN RESISTANT HYPERTENSION
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.083
DO  - 10.1016/j.artres.2018.10.083
ID  - Lopes2018
ER  -

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