P31 DO TREATMENT INDUCED CHANGES IN ARTERIAL STIFFNESS AFFECT LEFT VENTRICULAR STRUCTURE AND FUNCTION? – A META-ANALYSIS

Koen van der Waaij; Maarten Heusinkveld; Tammo Delhaas; Abraham Kroon; Koen Reesink

doi:10.1016/j.artres.2018.10.084

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Volume 24, Issue C, December 2018, Pages 88 - 88

P31 DO TREATMENT INDUCED CHANGES IN ARTERIAL STIFFNESS AFFECT LEFT VENTRICULAR STRUCTURE AND FUNCTION? – A META-ANALYSIS

Authors

Koen van der Waaij¹, Maarten Heusinkveld², Tammo Delhaas², Abraham Kroon³, Koen Reesink²

¹Department of Biomedical Engineering and Internal Medicine, CARIM School for Cardiovascular Diseases, the Netherlands

²Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands

³Department of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.084 How to use a DOI?
Abstract: Background: Vascular research demonstrated that pulse wave velocity (PWV), a measure of arterial stiffness, is inherently blood pressure-dependent. Considering the hypothesised pathophysiological chain of increased arterial stiffness leading to increased blood pressure load with consequent left ventricle hypertrophy (LVH) development, we conducted a systematic review of antihypertensive and lifestyle intervention studies to determine the association between on the one hand changes in arterial stiffness and blood pressure, and on the other hand changes in LV mass (LVM).

Methods: Using PubMed, EMBASE, Cochrane and Web of Science, we identified 23 studies, containing 2573 patients. Studies reported changes in arterial stiffness (assessed by means of PWV), systolic- and diastolic blood pressure (SBP, DBP), and LVM index (LVMI), respectively.

Results: Statistically significant reductions in SBP, PWV and LVMI were reported in 16, 14, and 20 studies, respectively. Pooled analysis of studies showed that the proportion in SBP reduction did not correlate significantly to the proportion in reductions of the other two variables. On the other hand, we found a significant positive correlation (r = 0.58, p = 0.007) between arterial stiffness and LVM regression, expressed as a relevant reduction in LVMI of 6.5 g/m² per 1.0 m/s reduction in PWV.

Conclusions: Our findings provide evidence that a decrease in arterial stiffness is associated with regression of LVH. To investigate whether there exists a causal relation between LVH due to arterial stiffness increases and in turn blood pressure load increases, future studies should strive for a multiple followup design and use of blood pressure-independent or -corrected stiffness indices.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 88 - 88
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.084 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Koen van der Waaij
AU  - Maarten Heusinkveld
AU  - Tammo Delhaas
AU  - Abraham Kroon
AU  - Koen Reesink
PY  - 2018
DA  - 2018/12/04
TI  - P31 DO TREATMENT INDUCED CHANGES IN ARTERIAL STIFFNESS AFFECT LEFT VENTRICULAR STRUCTURE AND FUNCTION? – A META-ANALYSIS
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.084
DO  - 10.1016/j.artres.2018.10.084
ID  - vanderWaaij2018
ER  -

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