Artery Research

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Volume 24, Issue C, December 2018, Pages 87 - 87

P27 INVASIVE CENTRAL PULSE PRESSURE IS RELATED TO AORTIC ROOT DILATATION

Authors
Francesco Tosello1, Andrea Guala2, Dario Leone1, Martina Bollati1, Luca Sabia1, Fabrizio D’Ascenzo3, Claudio Moretti3, Franco Veglio1, Luca Ridolfi4, Alberto Milan1
1Internal and Hypertension Division, Department of Medical Sciences, AOU Citta’ Salute e Scienza of Turin, University of Turin, Turin, Italy
2Vall d’Hebron Institute of Research, Barcelona, Spain
3Hemodynamic Laboratory, Department of Medical Sciences, AOU Citta’ Salute e Scienza of Turin, University of Turin, Turin, Italy
4DIATI, Politecnico di Torino, Turin, Italy
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.080How to use a DOI?
Abstract

Background: Aortic root dilation is an established risk factor for aortic dissection. Despite the relations between aortic root remodeling, carotid-femoral pulse wave velocity (cfPWV) and aortic blood pressure have been advocated by several clinical studies and is supported by physical law, invasive data are lacking. We aimed to investigate the relationship between aortic root remodeling, invasively-measured central blood pressure and cfPWV in patients referred for invasive hemodynamic evaluation for suspected coronary disease.

Methods: In 71 patients aortic pulse pressure (aoPP) was measured in the proximal aorta with a calibrated fluid-filled pressure catheter. Before entering the hemodynamic room all patients underwent 2D echocardiographic quantification of aortic root diameter and measurement of cfPWV. Aortic root diameter was then expressed into z-score following age, sex and height adjusted reference values (1).

Results: Mean age was 67 ± 10 years and 76.1% of patients were men. Invasive aortic systolic pressure was 146 ± 23 mmHg, diastolic pressure was 78 ± 13 mmHg, and aoPP was 68 ± 21 mmHg. Aortic Z-score was −0.32 ± 1.7, while CfPWV was 9.8±3 m/s. While Log10cfPWV and aoPP showed a positive relation (r=0.426, p<0.01) while aoPP and aortic Z-score were inversely associated (r = −0.271, p = 0.02). In a multivariable linear regression analysis, Z-score and Log10cfPWV were statistically-significant independent predictors of aoPP (p = 0.01 and p < 0.01, respectively) after adjustment for age, sex, BSA, heart rate, invasive MBP, and stroke volume.

Conclusions: In a population referred to invasive coronary hemodynamic evaluation for suspected coronary disease, aortic root remodeling and aortic stiffness were independently associated with a lower aoPP.

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This is an open access article distributed under the CC BY-NC license.

References

1.RB Devereux et al., Normal Limits in Relation to Age, Body Size and Gender of Two- Dimensional Echocardiographic Aortic Root Dimensions in Persons ≥15 Years of Age, American Journal of Cardiology, Vol. 110, 2012, pp. 1189-1194.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
87 - 87
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.080How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Francesco Tosello
AU  - Andrea Guala
AU  - Dario Leone
AU  - Martina Bollati
AU  - Luca Sabia
AU  - Fabrizio D’Ascenzo
AU  - Claudio Moretti
AU  - Franco Veglio
AU  - Luca Ridolfi
AU  - Alberto Milan
PY  - 2018
DA  - 2018/12/04
TI  - P27 INVASIVE CENTRAL PULSE PRESSURE IS RELATED TO AORTIC ROOT DILATATION
JO  - Artery Research
SP  - 87
EP  - 87
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.080
DO  - 10.1016/j.artres.2018.10.080
ID  - Tosello2018
ER  -