Artery Research

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Volume 24, Issue C, December 2018, Pages 89 - 90

P37 PULSE WAVE VELOCITY: DEPENDENCE ON CONTEMPORANEOUS AND HISTORICAL BLOOD PRESSURE COMPONENTS

Authors
Louise Keehn, Marina Cecelja, Phil Chowienczyk
Kings College London, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.090How to use a DOI?
Abstract

Background: Arterial stiffness as measured by PWV along the aorta is an important determinant of cardiovascular risk. PWV is known to be dependent on contemporaneous blood pressure (BP) but its dependence on long-term BP has not been established.

Methods: Subjects from Twins UK who had tonometric measures of carotid-femoral PWV with previous longitudinal measures of blood pressure (n = 2094) and, in a sub-sample, PWV (n=956) were studied. Brachial artery pulse pressure (PP) and mean arterial pressure (MAP) were averaged over the period of longitudinal follow-up to obtain measures of historical PP and MAP (PPH and MAPH). The relationship of PWV to contemporaneous PP and MAP (PPC and MAPC) was compared with that to PPH and MAPH.

Results: The average duration of blood pressure measurement was 14.0 ± 4.3 years.PWV correlated strongly with PPC (r = 0.542, p < 0.001), PPH (r = 0.474,p < 0.001), MAPC (r = 0.462, p < 0.001) and MAPH (r = 0.360, p < 0.001). In multiple regression analysis incorporating historical and contemporaneous values of PP and MAP as well as age and heart rate, PWV was significantly associated with PPC, MAPC and PPH but not with MAPH. In the sub-study in which historical values of PWV were available, PWV increased by 0.75 ± 1.42 m/s, over an average of 5.5 ± 1.7years. The change in PWV was associated with MAPC and with PPH (β = 0.144, p < 0.001).

Conclusions: These results are consistent with strong dependence of PWV on contemporaneous BP but also historical values of pulse pressure which may drive arterial stiffening.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
24 - C
Pages
89 - 90
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.090How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Louise Keehn
AU  - Marina Cecelja
AU  - Phil Chowienczyk
PY  - 2018
DA  - 2018/12/04
TI  - P37 PULSE WAVE VELOCITY: DEPENDENCE ON CONTEMPORANEOUS AND HISTORICAL BLOOD PRESSURE COMPONENTS
JO  - Artery Research
SP  - 89
EP  - 90
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.090
DO  - 10.1016/j.artres.2018.10.090
ID  - Keehn2018
ER  -