Artery Research

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Volume 24, Issue C, December 2018, Pages 82 - 82

P10 COMBINATION OF FLOW-MEDIATED DILATION AND PULSE WAVE VELOCITY PROVIDES FURTHER CARDIOVASCULAR RISK STRATIFICATION IN PATIENTS WITH CORONARY ARTERY DISEASE: FLOW-MEDIATED DILATION JAPAN STUDY A (FMD-J A)

Authors
Yukihito Higashi1, Tatsuya Maruhashi1, Hirofumi Tomiyama2, Bonpei Takase3, Toru Suzuki4, Yasuki Kihara1, Akira Yamashina5
1Hiroshima University, Hiroshima, Japan
2Tokyo Medical University, Toikyo, Japan
3National Defense Medical College Research Institute, Tokorozawa, Japan
4University of Leiceste, Leiceste, UK
5Tokyo Medical University, Tokyo, Japan
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.063How to use a DOI?
Abstract

Purpose/Background/Objective: The usefulness of vascular function tests for management of patients with coronary artery disease (CAD) has not been fully investigated.

Methods: We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with CAD for assessment of the predictive value of FMD and baPWV for cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death.

Results: A median follow-up period was 49.2 months. First primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver-operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio [HR], 0.27; 95% confidence interval [CI], 0.06–0.74; P = 0.008) and second (HR, 0.32; 95% CI, 0.09–0.79; P = 0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (HR, 1.86; 95% CI, 1.01–3.44; P = 0.04) and second (HR, 2.19; 95% CI, 1.23–3.90; P = 0.008) primary outcomes. Among the four groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed.

Conclusions: Both FMD and baPWV were independent predictors of cardiovascular events in patients with CAD. The combination of FMD and baPWV provided further cardiovascular risk stratification.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
24 - C
Pages
82 - 82
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.063How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Yukihito Higashi
AU  - Tatsuya Maruhashi
AU  - Hirofumi Tomiyama
AU  - Bonpei Takase
AU  - Toru Suzuki
AU  - Yasuki Kihara
AU  - Akira Yamashina
PY  - 2018
DA  - 2018/12/04
TI  - P10 COMBINATION OF FLOW-MEDIATED DILATION AND PULSE WAVE VELOCITY PROVIDES FURTHER CARDIOVASCULAR RISK STRATIFICATION IN PATIENTS WITH CORONARY ARTERY DISEASE: FLOW-MEDIATED DILATION JAPAN STUDY A (FMD-J A)
JO  - Artery Research
SP  - 82
EP  - 82
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.063
DO  - 10.1016/j.artres.2018.10.063
ID  - Higashi2018
ER  -