P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM

Isabela Biscotto; Valeria Costa-Hong; Luiz Bortolotto; Luciani Carvalho

doi:10.1016/j.artres.2018.10.072

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Volume 24, Issue C, December 2018, Pages 85 - 85

P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM

Authors

Isabela Biscotto¹, Valeria Costa-Hong², Luiz Bortolotto², Luciani Carvalho³

¹Hospital das Clínicas da Faculdade de Medicina da Universidade Sao Paulo, Brasil

²Instituto do coração, Hospital das Clinicas da Faculdade de Medicina da Universidade Sao Paulo, Brasil

³Hospital das Clínicas, da Faculdade de Medicina da Universidade São Paulo, Brasil

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.072 How to use a DOI?
Abstract: Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH).

Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1- hrGHr: 13 male, 14 female with median age 33.2 yrs, rhGHr in adult life with 7.38 yrs median time; 2 - Without hrGHr: 13 male, 11 female with 36.9 yrs median age and without hrGHr in adult life of 10.4 yrs median time. Anthropometric parameters, dual-energy X-ray absorptiometry (DEXA), lipid and glycemic profile, and structural and functional parameters of the arterial vessels (carotid intima media thickness, arterial stiffness and flow mediated dilation) were evaluated.

Results: The diagnosis of obesity and overweight was higher in patients without hrGHr. Among the anthropometric characteristics, the waist-to-height ratio and diastolic blood pressure were higher in patients without replacement (p = 0.03 and p = 0.019, respectively). In the evaluation of body composition through DEXA, the Fat Mass Index among patients under hrGHr was significantly lower than in patients without hrGHr (p = 0.029). Although no statistical difference in the vascular parameters between patients with and without hrGHr, it was observed a trend towards a higher arterial stiffness in the group without replacement (p = 0.051). In the group of patients without hrGHr, arterial stiffness had a significant and positive correlation with the time without hrGHr (p = 0.038).

Conclusions: These data suggest that the hrGHr in adults with COH may have protective effects on cardiovascular system.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 85 - 85
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.072 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Isabela Biscotto
AU  - Valeria Costa-Hong
AU  - Luiz Bortolotto
AU  - Luciani Carvalho
PY  - 2018
DA  - 2018/12/04
TI  - P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM
JO  - Artery Research
SP  - 85
EP  - 85
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.072
DO  - 10.1016/j.artres.2018.10.072
ID  - Biscotto2018
ER  -

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