Artery Research

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Volume 24, Issue C, December 2018, Pages 78 - 79

5.3 CAROTID ARTERY STIFFNESS INCREASES THE RISK OF INCIDENT DEPRESSIVE SYMPTOMS: THE PARIS PROSPECTIVE STUDY 3

Authors
Thomas van Sloten1, Pierre Boutouyrie2, Muriel Tafflet3, Lucile Offredo3, Frédérique Thomas4, Catherine Guibout5, Rachel Climie3, Cedric Lemogne6, Bruno Pannier4, Stephane Laurent2, Xavier Jouven3, Jean-philippe Empana3
1INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology and Arterial Mechanics, Paris, France
2INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Arterial Mechanics, Paris, France
3INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France
4Preventive and Clinical Investigation Center, Paris, France
5INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology, Paris, France
6INSERM, U894, Psychiatry and Neuroscience Center, Paris, France
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.050How to use a DOI?
Abstract

Background: Late-life depression is related to poor quality of life and increased risk of mortality and cardiovascular disease. Effective interventions for prevention and treatment of late-life depression need to be developed, which requires a better understanding of late-life depression risk factors. Arterial stiffness may contribute to late-life depression via cerebrovascular damage, but evidence is scarce.

Aim: To investigate the association between carotid artery stiffness and incident depressive symptoms in a large community-based cohort study.

Methods: This longitudinal study included 7,013 participants (60 (SD 6) years; 36% women) free of depressive symptoms at baseline. Carotid stiffness (high-resolution echotracking) was determined at baseline. Presence of depressive symptoms was determined at baseline and at 4 and 6 years of follow-up and was defined as a score ≥7 on a validated 13-item questionnaire (Q2DA) and/or new use of antidepressants. Logistic regression and generalized estimating equations (GEE) were used.

Results: In total, 6.9% (n = 484) of the participants had incident depressive symptoms at 4 or 6 years of follow-up. Greater carotid stiffness was associated with a higher incidence of depressive symptoms (Figure). Results were qualitatively similar when GEE was used instead of logistic regression.

Conclusions: Greater carotid artery stiffness is associated with a higher incidence of depressive symptoms. This study supports the hypothesis that carotid artery stiffness contributes to the development of late-life depression.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
78 - 79
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.050How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Thomas van Sloten
AU  - Pierre Boutouyrie
AU  - Muriel Tafflet
AU  - Lucile Offredo
AU  - Frédérique Thomas
AU  - Catherine Guibout
AU  - Rachel Climie
AU  - Cedric Lemogne
AU  - Bruno Pannier
AU  - Stephane Laurent
AU  - Xavier Jouven
AU  - Jean-philippe Empana
PY  - 2018
DA  - 2018/12/04
TI  - 5.3 CAROTID ARTERY STIFFNESS INCREASES THE RISK OF INCIDENT DEPRESSIVE SYMPTOMS: THE PARIS PROSPECTIVE STUDY 3
JO  - Artery Research
SP  - 78
EP  - 79
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.050
DO  - 10.1016/j.artres.2018.10.050
ID  - vanSloten2018
ER  -