3.3 ROLE OF ARTERIAL STIFFNESS AND BLOOD PRESSURE VARIABILITY IN THE DEFINITION OF SHATS (SYSTEMIC HEMODYNAMIC ATHEROTHROMBOTIC SYNDROME)

DOI

10.1016/j.artres.2018.10.034How to use a DOI?

Abstract

Background: CV risk exponentially increases as the number of damaged organs increases The Systemic Hemodynamic Atherosclerotic Syndrome (SHATS) represents a novel conceptualization of the CV continuum focusing on simultaneous multi-organ alteration. This is the first study operationally defining SHATS and aimed at identifying its determinants.

Methods: Left Ventricular Hypertrophy (echocardiography), Common Carotid Artery plaque and increased thickness (ultrasound), and Chronic Kidney Disease (estimated Glomerular Filtration Rate) indexed selective target organ damage. SHATS was operationally defined as their simultaneous presence in a patient. PWV was measured by Sphygmocor^® and BP variability by 24 h ABPM.

Results: SHATS affected 19.9% of the 367 studied subjects. Subjects with SHATS had a similar prevalence in diabetes mellitus, but a greater prevalence of very stiff artery (84.9 vs 64.3 %, p < 0.01) and use of antihypertensive medications. In the presence of similar office BP, SHATS was associated with higher 24 h SBP and lower 24 h DBP (a greater pulsatile pressure!), reduced nighttime SBP fall, and a twofold greater prevalence of reverse dipper status (48.2 vs 20.2 %, p < 0.001). BMI (positive correlation) and DBP (negative correlation) were the only traditional CV risk factors significantly associated with the odds of having SHATS. Very stiff artery and BP variability were significant independent determinants of SHATS, with highly predictive accuracy.

Conclusion: SHATS, the simultaneous damage of multiple target organs, may easily operationally defined. Very stiff artery and BP variability represent key factors for SHATS. The present results support the hypothesis of SHATS as a systemic condition, needing further characterization.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Angelo Scuteri
AU  - Valentina Rovella
AU  - Danilo Alunni Fegatelli
AU  - Manfredi Tesauro
AU  - Marco Gabriele
AU  - Nicola Di Daniele
PY  - 2018
DA  - 2018/12/04
TI  - 3.3 ROLE OF ARTERIAL STIFFNESS AND BLOOD PRESSURE VARIABILITY IN THE DEFINITION OF SHATS (SYSTEMIC HEMODYNAMIC ATHEROTHROMBOTIC SYNDROME)
JO  - Artery Research
SP  - 73
EP  - 73
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.034
DO  - 10.1016/j.artres.2018.10.034
ID  - Scuteri2018
ER  -