Artery Research

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Volume 24, Issue C, December 2018, Pages 73 - 73

3.4 A CLINICAL SCORE TO PREDICT ELEVATED ARTERIAL STIFFNESS: DERIVATION AND VALIDATION IN 3,943 HYPERTENSIVE PATIENTS

Authors
Panagiotis Xaplanteris1, Charalambos Vlachopoulos2, Athanasios Protogerou3, Konstantinos Aznaouridis2, Dimitris Terentes-Printzios2, Antonis Argyris3, Nikolaos Tentolouris3, Petros Sfikakis3, Dimitris Tousoulis2
1CHU Saint Pierre, Brussels, Belgium
2Hippokration Hospital, University of Athens, 1st Department of Cardiology, Athens, Greece
3Laiko University General Hospital, Cardiovascular Prevention and Research Unit, Department of Pathophysiology, Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.035How to use a DOI?
Abstract

Purpose/Background/Objectives: Aortic stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an important predictor to gauge the overall risk of hypertensive patients; nonetheless, it is underutilized in everyday practice. We derived a simple scoring system based on clinical variables that can identify patients with a priority for measurement of PWV, i.e. those with elevated PWV (≥ 10 m/sec) and at higher risk for events.

Methods: Patient data from three outpatient clinics (n = 3,943) were used to form a derivation, internal and external validation cohort. For derivation, independent predictors of high PWV from a binary logistic regression model were dichotomized and implemented in a clinical prediction scoring system with the acronym SAGE (office systolic blood pressure ≥160 mmHg: 4 points, age ≥ 60 years: 4 points, glycemia [blood glucose ≥126 mg/dl]: 1 point, eGFR ≤60: 2 points).

Results: Its performance was validated at the internal and external validation cohorts with c-statistics being 0.781 (95% CI: 0.753–0.808) and 0.718 (95% CI: 0.682–0.755) respectively (Figure 1). A cut-off of 5 points to identify patients with high PWV in the external validation cohort yielded a positive predictive value, negative predictive value, sensitivity and specificity of 60.7%, 84.8%, 51.9% and 78.3% respectively.

Conclusions: The SAGE score that takes into account easily measured clinical variables (systolic blood pressure, age, glucose and eGFR) can be used to predict elevated levels of PWV and prioritize its measurement in specific patients. Its use will result in greater acknowledgement of the role of aortic stiffness and aid physicians in implementing it in clinical practice.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
24 - C
Pages
73 - 73
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.035How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Panagiotis Xaplanteris
AU  - Charalambos Vlachopoulos
AU  - Athanasios Protogerou
AU  - Konstantinos Aznaouridis
AU  - Dimitris Terentes-Printzios
AU  - Antonis Argyris
AU  - Nikolaos Tentolouris
AU  - Petros Sfikakis
AU  - Dimitris Tousoulis
PY  - 2018
DA  - 2018/12/04
TI  - 3.4 A CLINICAL SCORE TO PREDICT ELEVATED ARTERIAL STIFFNESS: DERIVATION AND VALIDATION IN 3,943 HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 73
EP  - 73
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.035
DO  - 10.1016/j.artres.2018.10.035
ID  - Xaplanteris2018
ER  -