3.1 STRAIN DISCONTINUITIES IN CAROTID ATHEROSCLEROTIC PLAQUES – A NOVEL MARKER FOR PLAQUE VULNERABILITY?

DOI

10.1016/j.artres.2018.10.032How to use a DOI?

Abstract

Objective: Rupture of atherosclerotic plaques is ultimately a biomechanical event. We aim to develop and validate a novel method using ultrasound radiofrequency (RF) measurements to determine intraplaque inhomogeneities in the strain distribution with a high axial resolution which may identify rupture-prone plaques.

Methods: Ultrasound examinations were performed on CCAs and ICAs of 17 patients with recent stroke/TIA and 5 asymptomatic patients (39 CCAs and ICAs). Strain distribution was computed from RF data with a depth resolution <0.5 mm. In the plaque-free CCA, radial wall strain was compared with distension for validation. Two observers analyzed the data. In the ICAs, strain inhomogeneities in the plaque were studied.

Results: Within the CCA wall, the strain (observer 1: −7.4 ± 2.7%, observer 2: −6.4 ± 2.6%) had good intra-subject precision (1.6%), accuracy (correlation with relative distension, observer 1: r = 0.69; p < 0.0001, observer 2: r = 0.68; p < 0.0001) and intra-observer variability (ICC of 0.681). In the ICA, strain inhomogeneities demarcated in 58% of cases the plaque-adventitia boundary. The percentage of ICAs with ≥1 strain inhomogeneities was increasing with the degree of stenosis (p = 0.03, 95%-CI). Strain inhomogeneities were more frequent in ICAs at the symptomatic side of stroke/TIA (odd’s-ratio = 4.7; p = 0.07). Strain in the deviating strain regions was higher at the symptomatic compared to the asymptomatic side (p = 0.02).

Conclusion: The proposed method to assess local radial strain distribution proved to be accurate and precise. In ICA, areas with high strain inhomogeneities were more frequent in symptomatic plaques vs asymptomatic plaques. These strain inhomogeneities could be a promising novel marker for plaque vulnerability.

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TY  - JOUR
AU  - Tim Vonk
AU  - Evelien Hermeling
AU  - Floris Schreuder
AU  - Werner Mess
AU  - Eline Kooi
PY  - 2018
DA  - 2018/12/04
TI  - 3.1 STRAIN DISCONTINUITIES IN CAROTID ATHEROSCLEROTIC PLAQUES – A NOVEL MARKER FOR PLAQUE VULNERABILITY?
JO  - Artery Research
SP  - 71
EP  - 71
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.032
DO  - 10.1016/j.artres.2018.10.032
ID  - Vonk2018
ER  -