Artery Research

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Volume 24, Issue C, December 2018, Pages 72 - 73

3.2 RESERVOIR PRESSURE INTEGRAL IS INDEPENDENTLY ASSOCIATED WITH THE REDUCTION IN RENAL FUNCTION IN AN OLDER POPULATION

Authors
Kunihiko Aizawa1, Francesco Casanova1, David M. Mawson2, Kim M. Gooding1, W. David Strain1, Phillip E. Gates1, Gerd Östling3, Faisel Khan4, Helen M. Colhoun5, Carlo Palombo6, Kim H. Parker7, Jan Nilsson3, Angela C. Shore1, Alun D. Hughes8
1Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK
21Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK
3Department of Clinical Sciences, Lund University, Malmö, Sweden
4Division of Molecular & Clinical Medicine, University of Dundee, Dundee, UK
5Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK
6Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy
7Department of Bioengineering, Imperial College, London, UK
8Institute of Cardiovascular Science, University College London, London, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.033How to use a DOI?
Abstract

Background: Central haemodynamic parameters derived from reservoir pressure analysis (RPA-parameters) exhibit prognostic utility. Alterations in reservoir function could have an unfavourable influence on target organs, such as the kidneys. We determined in older adults whether these RPA-parameters would be associated with the reduction in estimated glomerular filtration rate (eGFR) during a 3-year follow-up period.

Methods: We studied 544 individuals (69.4 ± 7.9 yrs, 195F, 235CVD) at baseline and after 3 years. RPA-parameters including reservoir pressure integral (INTPR), peak reservoir pressure, excess pressure integral, systolic and diastolic rate constants were obtained by radial artery tonometry.

Results: After 3 years, 95 individuals (72.4 ± 7.6 yrs, 26F) had an eGFR reduction of more than 5 ml/min/1.73 m2/year. A multivariate logistic regression analysis revealed that baseline INTPR was independently associated with the eGFR reduction after adjusting for conventional risk factors and baseline renal function [odds ratio 0.975 (95% CI, 0.958–0.993), p < 0.01]. When the eGFR reduction was expressed as a continuous variable, baseline INTPR was also independently associated with changes in eGFR (β = 0.115, p < 0.01; multivariate linear regression with adjustment for conventional risk factors and baseline renal function). These associations remained unchanged after further adjustments for central artery stiffness or traditional central haemodynamic parameters. No other RPA-parameters exhibited significant associations.

Conclusions: These findings demonstrate that baseline INTPR is independently associated with the eGFR reduction in older adults, suggesting that INTPR may play a role in the functional decline of the kidneys.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
24 - C
Pages
72 - 73
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.033How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kunihiko Aizawa
AU  - Francesco Casanova
AU  - David M. Mawson
AU  - Kim M. Gooding
AU  - W. David Strain
AU  - Phillip E. Gates
AU  - Gerd Östling
AU  - Faisel Khan
AU  - Helen M. Colhoun
AU  - Carlo Palombo
AU  - Kim H. Parker
AU  - Jan Nilsson
AU  - Angela C. Shore
AU  - Alun D. Hughes
PY  - 2018
DA  - 2018/12/04
TI  - 3.2 RESERVOIR PRESSURE INTEGRAL IS INDEPENDENTLY ASSOCIATED WITH THE REDUCTION IN RENAL FUNCTION IN AN OLDER POPULATION
JO  - Artery Research
SP  - 72
EP  - 73
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.033
DO  - 10.1016/j.artres.2018.10.033
ID  - Aizawa2018
ER  -