Artery Research

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Volume 24, Issue C, December 2018, Pages 71 - 71

2.6 FEASIBILITY OF AORTIC WAVE INTENSITY ANALYSIS FROM SEQUENTIALLY ACQUIRED CARDIAC MRI AND NON-INVASIVE CENTRAL BLOOD PRESSURE

Authors
Anish Bhuva1, 2, Niro Nadarajan3, Andrew D’Silva4, Camilla Torlasco5, Redha Boubertakh2, Siana Jones3, Paul Scully3, 2, Rachel Bastiaenen4, Guy Lloyd2, Sanjay Sharma4, James Moon3, 2, Kim Parker6, Charlotte Manisty3, 2, Alun Hughes3, 7
1University College London, UK
2Barts Heart Centre, London, UK
3Institute of Cardiovascular Science, University College London, UK
4Cardiovascular Sciences Research Centre, St. George’s, University of London, London, United Kingdom
5IRCCS, Istituto Auxologico Italiano, Milan, Italy
6Department of Bioengineering, Imperial College London, UK
7MRC Unit for Lifelong Health and Ageing at UCL, London, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.029How to use a DOI?
Abstract

Background: Wave intensity analysis (WIA) in the aorta offers important clinical and mechanistic insights but is difficult non-invasively. We performed WIA by combining high temporal resolution cardiovascular magnetic resonance (CMR) flow velocity and non-invasive central blood pressure (BP) waveform data.

Method: 206 healthy volunteers (36 ± 11 years, 47% male) underwent sequential phase contrast CMR (Siemens Aera 1.5T, 1.97 x 1.77 mm2, ∼9 ms temporal resolution) and supra-systolic oscillometric central BP (Uscom Ltd BP+) measurement. Velocity (U) and central pressure (P) waveforms (200 Hz) were aligned using the wave foot, and local wave speed was calculated both from the P-U slope during early systole (c) and the sum of squares method (cSS) (Figure 1), and compared with CMR aortic arch pulse wave velocity (PWV) by transit time.

Results: The peak intensity of the initial compression wave (dI+1), backward compression wave (dI-) and protodiastolic decompression wave (dI + 2) were 69.5 ± 28, −6.6 ± 4.2 and 6.2 ± 2.5 W/m2 respectively. PWV correlated with c or cSS (r = 0.60, and 0.68 respectively; bias −1.3 [limits of agreement: −3.8 to 1.2 m/s], and bias −0.64 [limits of agreement: −3.0 to 1.7 m/s] respectively), Figure 1.

Conclusion: Wave intensity patterns and values are similar to those measured using invasive methods. Local wave speed showed good agreement with PWV. CMR and central blood pressure provides a novel non-invasive technique for performing wave intensity analysis and is feasible for large scale studies.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
71 - 71
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.029How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Anish Bhuva
AU  - Niro Nadarajan
AU  - Andrew D’Silva
AU  - Camilla Torlasco
AU  - Redha Boubertakh
AU  - Siana Jones
AU  - Paul Scully
AU  - Rachel Bastiaenen
AU  - Guy Lloyd
AU  - Sanjay Sharma
AU  - James Moon
AU  - Kim Parker
AU  - Charlotte Manisty
AU  - Alun Hughes
PY  - 2018
DA  - 2018/12/04
TI  - 2.6 FEASIBILITY OF AORTIC WAVE INTENSITY ANALYSIS FROM SEQUENTIALLY ACQUIRED CARDIAC MRI AND NON-INVASIVE CENTRAL BLOOD PRESSURE
JO  - Artery Research
SP  - 71
EP  - 71
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.029
DO  - 10.1016/j.artres.2018.10.029
ID  - Bhuva2018
ER  -