Artery Research

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Volume 24, Issue C, December 2018, Pages 69 - 70

2.2 GREATER BLOOD PRESSURE VARIABILITY IS ASSOCIATED WITH LOWER COGNITIVE PERFORMANCE – THE MAASTRICHT STUDY

Authors
Tan Lai Zhou1, 2, Abraham Kroon3, 2, Coen Stehouwer3, 2, Martin van Boxtel4, Frans Verhey4, Miranda Schram3, 2, 5, Thomas van Sloten6, 7, 2, Ronald Henry3, 2, 5
1Dept. of Internal Medicine, Maastricht University, Maastricht, the Netherlands
2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands
3Dept. of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands
4School for Mental Health and Neuroscience, Dept. of Psychiatry & Neuropsychology, Maastricht University, Maastricht, the Netherlands
5Heart and Vascular Centre, Maastricht University Medical Centre, Maastricht, the Netherlands
6Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France
7INSERM, UMR-S970, Paris Cardiovascular Research Center, Department of Epidemiology and Department of Arterial Mechanics, Paris, France
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.025How to use a DOI?
Abstract

An increasing number of individuals will face age-related cognitive difficulties, as life expectancy has increased globally. It is therefore important to identify modifiable risk factors for cognitive impairment. Very short- to mid-term blood pressure variability (BPV) may be such factor, as it may cause cerebral ischemia via various mechanisms. To this end, we investigated whether greater diastolic (dBPV) and systolic BPV (sBPV) are cross-sectionally associated with memory function (MF; n = 1804), information processing speed (IPS; n = 1793), and executive function (EF; n = 1780), in 40- to 75-year-old individuals from The Maastricht Study. A composite BPV-index was derived by standardizing and averaging within-visit, 24-hour and 7-day BPV. We performed linear regression with adjustments for age, sex, educational level, 24-hour DBP or SBP, and cardiovascular risk factors. We found that a 1-SD greater dBPV was associated with lower IPS (beta [SD difference]; 95% CI: -0.10;-0.20 to -0.00) and EF (-0.12; -0.22 to -0.01), and borderline associated with lower MF (-0.09; -0.20 to 0.01). A 1-SD greater sBPV, however, was not associated with IPS (-0.040; -0.14 to 0.06), or EF (-0.09; -0.20 to 0.022), but was borderline associated with lower MF (-0.11; -0.21 to 0.00). This effect of greater dBPV on cognitive performance is equivalent to ±3 additional years of ageing. The stronger association of dBPV than sBPV with cognitive performance may be explained by the fact that DBP is the main determinant of MAP. Excessive dBPV may then lead to inadequate cerebral perfusion. In conclusion, greater very short-to mid-term dBPV and, to a lesser extent, sBPV could be a modifiable risk factor for cognitive impairment.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
69 - 70
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.025How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Tan Lai Zhou
AU  - Abraham Kroon
AU  - Coen Stehouwer
AU  - Martin van Boxtel
AU  - Frans Verhey
AU  - Miranda Schram
AU  - Thomas van Sloten
AU  - Ronald Henry
PY  - 2018
DA  - 2018/12/04
TI  - 2.2 GREATER BLOOD PRESSURE VARIABILITY IS ASSOCIATED WITH LOWER COGNITIVE PERFORMANCE – THE MAASTRICHT STUDY
JO  - Artery Research
SP  - 69
EP  - 70
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.025
DO  - 10.1016/j.artres.2018.10.025
ID  - Zhou2018
ER  -