Artery Research

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Volume 24, Issue C, December 2018, Pages 67 - 67

1.1 PROMOTION OF ARTERIAL STIFFNESS BY CHILDHOOD CANCER AND ITS CHARACTERISTICS IN ADULT LONG-TERM SURVIVORS

Authors
Natalie Arnold1, Hiltrud Merzenich2, Arthur Wingerter3, Andreas Schluz4, Astrid Schneider2, Jürgen H. Prochaska5, Sebastian Göbel6, Marie-Astrid Neu3, Nicole Henninger3, Marina Panova-Noeva5, Susan Eckerle3, Claudia Spix2, Irene Schidtmann2, Karl J. Lackner7, Manfred E. Beutel8, Norbert Pfeiffer9, Thomas Münzel6, Jörg Faber3, Philipp S. Wild4
1University Medical Center of the Johannes Gutenberg-University Mainz, Germany
2Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
3Department of Pediatric Hematology/Oncology/Hemostaseology, Center for Paediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
4Preventive Cardiology and Preventive Medicine, Centre for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
5Center for Thrombosis and Haemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
6Center for Cardiology – Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
7Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
8Clinic for Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
9Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.018How to use a DOI?
Abstract

Background: Vascular alterations induced by antineoplastic treatment might be considered as a possible underlying mechanism of increased cardiovascular (CV) sequelae in childhood cancer survivors (CCS). Therefore, we thought to evaluate the changes in arterial stiffness (AS) among long-term CCS compared to the general population.

Methods: AS was assessed by digital photoplethysmography (Stiffness Index (SI); m/s) among 1,002 participant of “Cardiac and Vascular late Sequelae in long-term Survivors of childhood cancer” study, diagnosed with neoplasia prior to an age of 15 years (1980–1990). A population-based subsample from the Gutenberg Health Study (GHS) (n = 5,252) was used for comparison. All subjects underwent a comprehensive, standardized clinical examination in the same study center.

Results: Compared to the population subsample with similar age range, CCS had higher SI in multivariable linear regression analysis with adjustment for cardiovascular risk factor and comorbidities (β = 0.66[0.51/0.80]; p < 0.0001). Moreover, SI was varying according to tumor entity with highest values in bone tumors. Interestingly, CCS demonstrated stiffer vessels than individuals from the population even in absence of a history of chemo- or radiotherapy (β = 0.56[0.16/0.96]; p = 0.0066) or prevalent hypertension (β = 0.66[0.50/0.81]; p < 0.0001) in fully-adjusted models. Finally, a 5.2-fold [3.9; 7.0] higher prevalence of SI values exceeding age-specific, population-based reference limits was observed among CCS compared to individuals from the population.

Conclusions: This is the first study demonstrating increased AS among long-term CCS. The data suggest that AS promotion might differ in individuals with childhood cancer: Cancer development and antineoplastic treatment might be relevant determinants.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
67 - 67
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.018How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Natalie Arnold
AU  - Hiltrud Merzenich
AU  - Arthur Wingerter
AU  - Andreas Schluz
AU  - Astrid Schneider
AU  - Jürgen H. Prochaska
AU  - Sebastian Göbel
AU  - Marie-Astrid Neu
AU  - Nicole Henninger
AU  - Marina Panova-Noeva
AU  - Susan Eckerle
AU  - Claudia Spix
AU  - Irene Schidtmann
AU  - Karl J. Lackner
AU  - Manfred E. Beutel
AU  - Norbert Pfeiffer
AU  - Thomas Münzel
AU  - Jörg Faber
AU  - Philipp S. Wild
PY  - 2018
DA  - 2018/12/04
TI  - 1.1 PROMOTION OF ARTERIAL STIFFNESS BY CHILDHOOD CANCER AND ITS CHARACTERISTICS IN ADULT LONG-TERM SURVIVORS
JO  - Artery Research
SP  - 67
EP  - 67
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.018
DO  - 10.1016/j.artres.2018.10.018
ID  - Arnold2018
ER  -