13.04 LACK OF ENDOTHELIAL DYSFUNCTION IN BUERGER’S DISEASE
- DOI
- 10.1016/S1872-9312(07)70022-4How to use a DOI?
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- This is an open access article distributed under the CC BY-NC license.
Objective: To compare the acute flow-dependent vasodilatation (FDV) to a hand warming test (from 28°C to 44°C) and endothelium-independent vasodilatation (EIV) to sublingual glyceryl trinitrate (GTN 150 μg) of the brachial artery (BA) in 10 patients with an acute-phase Buerger disease, defined by an ADAR score ⩾4 and a recent ulcer of the lower limbs (7 current), and 10 age- and sex-matched non-smokers healthy subjects.
Methods: BA diameter and shear stress were recorded by high definition echotracking. FDV was estimated by the slope of diameter-shear stress relationship.
Results: See the table.
| median [IQR] | P value | ||
|---|---|---|---|
| Buerger | Control | ||
| FDV: Δ BA diameter (%) | 6.8 (0.1;8.1) | 3.7 (1.1;6.5) | ns |
| FDV: Δ shear stress (%) | 70 (32;100) | 93 (57;125) | ns |
| EIV: Δ BA diameter (%) | 30 (28;33) | 17 (13;22) | ns |
| EIV: Δ shear stress (%) | 98 (40;137) | 117 (76;251) | ns |
| Slope diameter-stress | 0.89 (0.55;1.24) | 0.28 (−0.01;0.58) | 0.025 |
Buerger’s patients had an enhanced flow-dependent response to the increase in shear stress due to hand warming by comparison with controls as shown by the higher slope of diameter-shear stress relationship.
Conclusions: Acute flow-mediated changes in brachial artery diameter during hand hyperhemia and EIV to GTN were not impaired in patients compared to control, by contrast to what has been repeatedly suggested in the literature.
Cite this article
TY - JOUR AU - A. Bura AU - P. Boutouyrie* AU - S. Peyrard AU - J.N. Fiessinger AU - S. Laurent AU - M. Azizi PY - 2007 DA - 2007/06/13 TI - 13.04 LACK OF ENDOTHELIAL DYSFUNCTION IN BUERGER’S DISEASE JO - Artery Research SP - S27 EP - S27 VL - 1 IS - S1 SN - 1876-4401 UR - https://doi.org/10.1016/S1872-9312(07)70022-4 DO - 10.1016/S1872-9312(07)70022-4 ID - Bura2007 ER -