09.02 RELATIONSHIP BETWEEN GROWTH AND AORTIC STIFFNESS IN EARLY YEARS OF LIFE
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- 10.1016/S1872-9312(07)70016-9How to use a DOI?
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Introduction: The exact course of aortic stiffness in early years of life is not known. This study was designed to test the relationship between aortic pulse wave velocity (aPWV) and the parameters of growth amongst children aged between 0 and 2 years. Our hypothesis was that aPWV is influenced by growth velocity.
Methods: Data was obtained from 517 baby-visits between 0 to 24 months of age, and included measurement of weight, length, blood pressure (BP) and aPWV.
Results: The weight, BMI and rate of BMI change are associated with aPWV and BP at birth, 1 and 2 years of age as shown in the table. aPWV increased by 6% from birth to 12 months and 37% from 12 to 24 months with an overall increase from birth to 24 months of 45%. Adjusting for gender, ethnicity, weight-rate and height, pulse pressure was found to be independently influenced by pulse pressure at age of 1 year (Beta = −0.027, p = 0.030; 95% CI −0.05 to −0.003), but this association was lost at age of 2 years.
| Weight | At birth | 1 year | 2 years | ||||
|---|---|---|---|---|---|---|---|
| Weight | BMI | BMI rate 0–1 | Weight | BMI | BMI rate 0–2 | ||
| aPWV | r = 0.29, p=0.001 | ||||||
| SBP | r = 0.30, p < 0.001 | r=0.24, p=0.002 | r=0.24, p=0.006 | r=0.46, p < 0.001 | r=0.36, p < 0.001 | r=0.27, p=0.013 | |
| DBP | r = 0.19, p=0.017 | r = 0.241, p=0.007 | |||||
Conclusions: Aortic stiffness is associated with increasing age, weight and BMI, as well as the rate of change of the latter two. All these variables are recognised cardiovascular risk factors and should be controlled from an early age.
Cite this article
TY - JOUR AU - M.E. Phitidis* AU - N. Bansal AU - A. Koudsi AU - M. Banerjee AU - A. Vyas AU - I. Gemmell AU - O. Ayoola AU - P. Clayton AU - J.K. Cruickshank PY - 2007 DA - 2007/06/13 TI - 09.02 RELATIONSHIP BETWEEN GROWTH AND AORTIC STIFFNESS IN EARLY YEARS OF LIFE JO - Artery Research SP - S26 EP - S26 VL - 1 IS - S1 SN - 1876-4401 UR - https://doi.org/10.1016/S1872-9312(07)70016-9 DO - 10.1016/S1872-9312(07)70016-9 ID - Phitidis*2007 ER -