OR-04 IMPORTANCE OF TIME DELAY ESTIMATION METHODS FOR AORTIC PULSE WAVE VELOCITY ASSESSMENT WITH PHASE-CONTRAST MRI
- DOI
- 10.1016/j.artres.2014.09.004How to use a DOI?
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Background: Pulse wave velocity (PWV) is a validated measure of arterial wall stiffness. Assessments of PWV are highly dependent on pulse transit time estimations between 2 points. No systematic assessments have been performed regarding the best method to assess pulse travel time using phase-contrast MRI.
Aim: To compare the relationship between MRI-derived PWV (distance/transit time) measured by different methods and: (1) Age; (2) Carotidfemoral PWV (CFPWV) assessed with arterial tonometry, the “gold standard” index of arterial stiffness.
Methods: We measured aortic flow using in plane phase contrast MRI in the “candy cane” aortic view among 261 adults. Transit time between the proximal ascending aorta and the distal thoracic descending aorta were assessed from flow velocity curves using various methods for pulse upstroke detection (table).
| Method | Age | CF PWV |
|---|---|---|
| R Value (P Value) | R Value (P Value) | |
| 2nd derivative | 0.43 (<0.0001) | 0.48 (<0.0001) |
| Cross-correlation | 0.12 (0.11) | 0.41 (<0.0001) |
| DPDT | 0.29 (<0.0001) | 0.44 (<0.0001) |
| 20% PH | 0.42 (<0.0001) | 0.46 (<0.0001) |
| 10% | 0.22 (0.001) | 0.38 (<0.0001) |
| 40% | 0.34 (<.0001) | 0.46 (<0.0001) |
| Intersecting tangents | 0.35 (<0.0001) | 0.42 (<0.0001) |
Results: Aortic PWV assessed based on the peak second derivative of flow demonstrated the best correlation with both age and tonometric CFPWV. The method based on 20% of the upstroke amplitude provided results comparable to the peak second derivative. On the other hand, the cross-correlation method (which is currently the most commonly used) demonstrated weak relationships and often resulted in non-physiologic PWV values (up to >200 m/sec) due to non-parallel up-slopes resulting in falsely short delays between cross-correlated upstrokes. Other methods provided intermediate correlation coefficients with age and CFPWV.
Conclusions: The method to compute the onset of the flow pulsatile up-stroke using phase-contrast MRI markedly impacts the assessment of PWV. The peak of the 2nd derivative is the most robust method for PWV estimations. The use of the cross-correlation method, which is most frequently used at present, should be abandoned.
Cite this article
TY - JOUR AU - Priyanka Bhattacharya AU - Chandrahasa Sharabu AU - Deepa Rawat AU - Scott Akers AU - Anjaneyulu Dunde AU - Prithvi Shivakumar AU - Prasad Konda AU - Walter Witschey AU - Payman Zamani AU - Julio A. Chirinos PY - 2014 DA - 2014/11/04 TI - OR-04 IMPORTANCE OF TIME DELAY ESTIMATION METHODS FOR AORTIC PULSE WAVE VELOCITY ASSESSMENT WITH PHASE-CONTRAST MRI JO - Artery Research SP - 165 EP - 165 VL - 8 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2014.09.004 DO - 10.1016/j.artres.2014.09.004 ID - Bhattacharya2014 ER -