Artery Research

Volume 1, Issue 2, September 2007, Pages 73 - 73

P.091 A PATIENT SPECIFIC WAVE PROPAGATION MODEL OF THE UPPER LIMB

Authors
C.A.D. Leguy1, E.M.H. Bosboom1, A.P.G. Hoeks2, F.N. Van de Vosse1
1University Hospital Maastricht, Maastricht, Netherlands
2Cardiovascular Research Institute Maastricht, Maastricht, Netherlands
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.025How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

In this study, a patient specific lumped parameter model is used to investigate pressure wave propagation phenomena and estimate mechanical properties of large arteries of the upper limb.

A set of local ultrasound measurements was obtained from a group of 7 healthy volunteers to provide vessel wall distension (WD) and blood velocity at several positions. Blood volume flow (BVF) is estimated from the centerline velocity using the Womersley profile method. The lumped parameters R, L, C along the arm are computed with a linear interpolation method from local blood pressure (BP) and WD. Thus, an entire arterial tree model, from the arm pit to the wrist, modeling the brachial, radial and ulnar arteries, is built. Time average BVF and BP values are used to determine the end impedance of the extremities. The BVF at the more proximal site is used as input for the simulations.

Simulated BVF and BP curves are compared with the in-vivo results. A reverse method adapts the model parameters resulting in values reflecting physiological results.

The results show that the shape of the simulated BVF along the arm is comparable with the in-vivo estimations. However, large differences are observed between simulated BP and in-vivo assessed WD curves. We hypothesize that those differences are due to the non-linear and visco-elastic properties of the arterial wall. Therefore, a continuous wave propagation model which takes those properties into account should be implemented. The experimental simulations provide and suggest improved physiological modeling of the pressure/flow relationships.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
73 - 73
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.025How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - C.A.D. Leguy
AU  - E.M.H. Bosboom
AU  - A.P.G. Hoeks
AU  - F.N. Van de Vosse
PY  - 2007
DA  - 2007/08/30
TI  - P.091 A PATIENT SPECIFIC WAVE PROPAGATION MODEL OF THE UPPER LIMB
JO  - Artery Research
SP  - 73
EP  - 73
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.025
DO  - 10.1016/j.artres.2007.07.025
ID  - Leguy2007
ER  -