Purpose: To investigate the interrelations of carotid-radial PWV (PWV-cr) and its dynamics in occlusion test with 24-h BP-monitoring (ABPM) parameters in patients with isolated systolic arterial hypertension (ISH).

Methods: 112 ISH patients were exposed to ABPM. PWV-cr (“PulseTracePWV”, Great Britain) was measured along with its dynamics (%) after a 5-min forearm cuff occlusion and the second measurement. According to the results of the occlusion test the patients formed two subgroups, in one of which PWV-cr decreased (n=66, 58.9%), while in the second group (n=46, 41.1%) it did not change or increased. In both groups mean parameters of ABPM were compared. Correlation and logistic regression analyses were applied.

Results: Initial PWV-cr of all patients correlated directly to diurnal diastolic BP (DBP) (r=0.40, p<0.0001). Inverse correlation was revealed between PWV-cr and low systolic BP (SBP) and DBP loads. The subgroups were similar in gender, age and 24-h SBP and DBP levels. At the same time the first subgroup nighttime SBP and DBP dipping indices were lower (р=0.0005 and 0.003) and nighttime DBP and SBP were higher (р=0.005 and 0.007) than those of the second group. Regression analysis showed that PWV-cr decrease is associated with non-dipping SBP and DBP patterns (OR=3.4, p=0.002 and OR=3.8, p=0.007).

Conclusion: In ISH patients the growth of peripheral arteries elasticity is followed by arterial hypotension prolongation during a day. PWV-cr dynamics in the occlusion test can have the predictive value in BP circadian rhythm disturbances assessment.