Artery Research

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Volume 1, Issue 2, September 2007, Pages 59 - 59

P.028 EPIGENETIC INTERACTION BETWEEN α-ADDUCIN AND RENIN-ANGIOTENSIN-SYSTEM GENES IN RELATION TO THE ELASTIC PROPERTIES OF THE FEMORAL ARTERY

Authors
J.S. Seidlerova1, J.A.S. Staessen1, T.N. Nawrot1, HAS.-B. Struijker-Boudier2, T.K. Kuznetsova1, G.B. Bianchi3, E.B. Brand4, SMB.-H. Brand-Hermann5, R.F. Fagard1, J.F. Filipovsky6
1Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseasese, University of Leuven, Leuven, Belgium
2The Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht, Netherlands
3Divisione di Nefrologia Dialisi e Ipertensione, Ospedale San Raffaele, Universitá Vita Salute, Milan, Italy
4Department of Internal Medicine D, University Clinic, Münster, Germany
5Department of Molecular Genetics of Cardiovascular Disease, Leibniz Institute for Arteriosclerosis Research, Münster, Germany
6The Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.085How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: We previously demonstrated that epigenetic interaction between the α-adducin (ADD1) Gly460Trp and the ACE I/D polymorphism modulates the properties of the femoral artery. Here, we investigated multiple-gene interactions between ADD1, ACE and other genes of the renin-angiotensin system: angiotensinogen (AGT) C-532T, G-6A, and angiotensin II receptor type 1 (AGTR1) A1166C.

Methods and results: We assessed the properties of the femoral artery with a wall-track system in a family-based random sample of 1064 subjects (participation rate 64.3%, mean age 43.6 years, 50.4% women). In population-based analyses, we computed phenotype-genotype associations, while adjusting for confounders, life style, and family clusters. In family-based analyses, we used a multivariate-adjusted quantitative transmission disequilibrium test (QTDT).

Results: In ADD1 Trp allele carriers, but not in ADD1 GlyGly homozygotes, AGTR1 AA subjects had lower femoral cross-sectional compliance (0.649 ± 0.030 vs 0.742 ± 0.029 mm2/kPa, P=0.027) and a lower distensibility coefficient (10.18 ± 0.43 vs 11.27 ± 0.41 10−3/kPa, P=0.067) than AGTR1 C allele carriers. QTDT confirmed these associations. The between-family component of phenotypic variability was not significant, suggesting that there was not population stratification. None of the gene-gene interactions involving AGT was statistically significant (P≥0.088).

Conclusions: The ADD1 Gly460Trp, AGTR1 A1166C and ACE I/D jointly influence the functional properties of the femoral artery.

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Journal
Artery Research
Volume-Issue
1 - 2
Pages
59 - 59
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.085How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - J.S. Seidlerova
AU  - J.A.S. Staessen
AU  - T.N. Nawrot
AU  - HAS.-B. Struijker-Boudier
AU  - T.K. Kuznetsova
AU  - G.B. Bianchi
AU  - E.B. Brand
AU  - SMB.-H. Brand-Hermann
AU  - R.F. Fagard
AU  - J.F. Filipovsky
PY  - 2007
DA  - 2007/08/30
TI  - P.028 EPIGENETIC INTERACTION BETWEEN α-ADDUCIN AND RENIN-ANGIOTENSIN-SYSTEM GENES IN RELATION TO THE ELASTIC PROPERTIES OF THE FEMORAL ARTERY
JO  - Artery Research
SP  - 59
EP  - 59
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.085
DO  - 10.1016/j.artres.2007.07.085
ID  - Seidlerova2007
ER  -