P.025 INCREASED ARTERIAL STIFFNESS AMONGST HEALTHY SOUTH ASIANS IN THE UNITED KINGDOM IN THE ABSENCE OF RAISED BLOOD PRESSURE
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Background: The pathophysiology of increased coronary heart disease (CHD) risk affecting South Asians(SA) living in Britain remains unclear. For a given blood pressure SA have a higher risk of CHD than the indigenous European Caucasian(EC). We hypothesised that measures of arterial stiffness would be greater amongst healthy SA compared to EC counterparts specifically, in the absence of raised blood pressure and established CHD risk indices.
Methods: Arterial stiffness was measured by digital volume pulse photoplethysmography(Micromedicals PCA 2) in 90 healthy SA (and compared to age-gender matched 62 EC in a temperature controlled environment using a standard protocol.
Results: SA and EC’s were comparable for CVD risk profile (Table 1). South Asians had an increased Stiffness Index compared to European Caucasians (9.43(0.22) vs. 8.53(0.23) m/s, P=0.007). In linear regression waist hip ratio and mean blood pressure were independent predictors of arterial stiffness (β=0.26, P=0.03).
| Risk factor Mean (SD) | South Asian (n=90) | European Caucasian (n=62) | P Value |
|---|---|---|---|
| Mean age (years) | 45.21(13.45) | 46.76(11) | 0.13 |
| Body Mass Index(BMI)Kg/m2 | 25.9(3.2) | 27.4(4.5) | 0.08 |
| Waist Hip Ratio(WHR) | 0.94(0.08) | 0.93(0.08) | 0.53 |
| Systolic blood pressure(mmHg) | 134.56(20.3) | 135.31(15.33) | 0.82 |
| Diastolic blood pressure(mmHg) | 83.64(12.35) | 83.58(10.09) | 0.97 |
| Serum cholesterol (mmol/l) | 4.45(1.4) | 4.66(0.72) | 0.94 |
| Fasting blood sugar(mmol/l) | 4.99(1.4) | 4.56(0.92) | 0.43 |
| P values using unpaired ttest comparing two groups | |||
Conclusion: South Asians have an increased wave reflection and systemic arterial stiffness compared to European Caucasians. Pathophysiological differences in vessel wall characteristics in South Asians may explain their increased susceptibility to higher cardiovascular risk and further work is warranted.
Cite this article
TY - JOUR AU - A. Gunarathne AU - J.V. Patel AU - R. Potluri AU - R. Butt AU - B. Gammon AU - C. Boos AU - N. Panja AU - E.A. Hughes AU - G.Y.H. Lip PY - 2007 DA - 2007/08/30 TI - P.025 INCREASED ARTERIAL STIFFNESS AMONGST HEALTHY SOUTH ASIANS IN THE UNITED KINGDOM IN THE ABSENCE OF RAISED BLOOD PRESSURE JO - Artery Research SP - 58 EP - 58 VL - 1 IS - 2 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2007.07.082 DO - 10.1016/j.artres.2007.07.082 ID - Gunarathne2007 ER -