P.002 HABITUAL ANTIOXIDANT VITAMIN INTAKE, AUGMENTATION INDEX AND FLOW MEDIATED DILATION IN HYPERTENSIVE PATIENTS AND NORMOTENSIVE CONTROLS

Y. Plantinga; L. Ghiadoni; A. Magagna; S. Salvini; M. Ceroti; G. Masala; D. Palli; S. Taddei; A. Salvetti

doi:10.1016/j.artres.2007.07.059

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Volume 1, Issue 2, September 2007, Pages 53 - 53

P.002 HABITUAL ANTIOXIDANT VITAMIN INTAKE, AUGMENTATION INDEX AND FLOW MEDIATED DILATION IN HYPERTENSIVE PATIENTS AND NORMOTENSIVE CONTROLS

Authors

Y. Plantinga¹, L. Ghiadoni¹, A. Magagna¹, S. Salvini², M. Ceroti², G. Masala², D. Palli², S. Taddei¹, A. Salvetti¹

¹University of Pisa, Pisa, Italy

²CSPO, Florence, Italy

Available Online 30 August 2007.

DOI: 10.1016/j.artres.2007.07.059 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Objective: We evaluated the association of daily dietary intake of antioxidants vitamins C and E with augmentation index and endothelial function in untreated essential hypertensive (HT) patients and normotensive (NT) subjects.

Methods: Dietary intake of major nutrients, total caloric intake and antioxidant vitamins were assessed with the Italian EPIC questionnaire in 200 untreated HT patients and 130 NT subjects. Augmentation index (AIx) was determined with radial applanation tonometry. Endothelium-dependent response was assessed as flow mediated dilation (FMD) of the brachial artery by high resolution ultrasounds and computerized analysis (automatic edge detection system) of brachial artery diameter modifications.

Results: AIx was significantly higher in HT patients (26.9 ± 9.6%) as compared to NT subjects (20.4 ± 11.3%), whereas FMD resulted significantly lower (5.0 ± 2.5 vs 6.2 ± 2.7; p<0.001). Calculated intake of vitamic C and E was similar in HT patients and in NT subjects (Vitamin C median 146.4± 68.7 mg/day and 149.1± 84.0 mg/day, Vitamin E median 8.68± 2.7 mg/day and 8.63± 2.9 mg/day, respectively). Multivariate analyses were controlled for smoking, physical activity status and total caloric intake. In both groups, levels of Vitamin C or E intake were not significant predictors for AIx. Finally, in both groups, levels of Vitamin C or E intake were not significant predictors for FMD.

Conclusions: No association exists between normal levels of regular food antioxidant intake, augmentation index and endothelial function in untreated essential hypertensive patients and normotensive subjects. This suggests that supplementation with vitamin C and E is necessary to show an effect on vascular function in this population.

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Journal: Artery Research
Volume-Issue: 1 - 2
Pages: 53 - 53
Publication Date: 2007/08/30
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2007.07.059 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Y. Plantinga
AU  - L. Ghiadoni
AU  - A. Magagna
AU  - S. Salvini
AU  - M. Ceroti
AU  - G. Masala
AU  - D. Palli
AU  - S. Taddei
AU  - A. Salvetti
PY  - 2007
DA  - 2007/08/30
TI  - P.002 HABITUAL ANTIOXIDANT VITAMIN INTAKE, AUGMENTATION INDEX AND FLOW MEDIATED DILATION IN HYPERTENSIVE PATIENTS AND NORMOTENSIVE CONTROLS
JO  - Artery Research
SP  - 53
EP  - 53
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.059
DO  - 10.1016/j.artres.2007.07.059
ID  - Plantinga2007
ER  -

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