Artery Research

Volume 1, Issue 2, September 2007, Pages 51 - 51

06.07 EVALUATION OF A METHOD OF WAVE REFLECTION ASSESSMENT VIA TRIANGULAR FLOW WAVE APPROXIMATION

Authors
J.G. Kips1, E.R. Rietzschel2, M.L. De Buyzere2, T.C. Gillebert2, L.M. Van Bortel1, P. Segers3
1Department of Pharmacology, Ghent University, Ghent, Belgium
2Department of Cardiovascular Diseases, Ghent University, Ghent, Belgium
3Institute of Biomedical Technology, Ghent University, Ghent, Belgium
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.052How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: Wave reflections affect the aortic pressure and flow wave and play a role in systolic hypertension. Accurate quantification of pressure wave reflection requires separation of pressure in its forward (Pf) and backward (Pb) components, which requires aortic flow measurement. This limitation can be overcome by replacing the unknown flow wave by a triangular estimate of arbitrary amplitude, as recently proposed. We verified this technique using pressure and flow data measured in the Asklepios study (>2500 participants, 35 to 55 years).

Method: Wave separation analysis using measured pressure and flow yielded the reference reflection magnitude (RM=Pb/Pf). Then, RM was estimated using three triangular approximations of the flow wave, each with duration equal to the ejection time but with peak at (i) the shoulder point of the pressure wave (FtSP);(ii) 30% of the ejection time (Ft30) and (iii) the moment of real peak flow (FtQm).

Results: The correlation between measured and estimated RM’s was highly significant (P<0.001) but overall disappointingly poor (R2=0.21 to 0.25), the highest correlation coefficient being obtained when using (FtQm). Overall, the approximation overestimated RMref by 10 to 12%. Interestingly, we found the accuracy of all estimations to depend highly on age (P<0.001), with the accuracy improving with age.

Conclusion: In healthy middle-aged subjects, quantification of wave reflection by estimating a triangular flow wave shows limited accuracy, even when timing of the peak is obtained directly from the flow waveform. This seems to imply that the triangular shape may be a too simple waveform approximation in this population.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
51 - 51
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.052How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J.G. Kips
AU  - E.R. Rietzschel
AU  - M.L. De Buyzere
AU  - T.C. Gillebert
AU  - L.M. Van Bortel
AU  - P. Segers
PY  - 2007
DA  - 2007/08/30
TI  - 06.07 EVALUATION OF A METHOD OF WAVE REFLECTION ASSESSMENT VIA TRIANGULAR FLOW WAVE APPROXIMATION
JO  - Artery Research
SP  - 51
EP  - 51
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.052
DO  - 10.1016/j.artres.2007.07.052
ID  - Kips2007
ER  -