Artery Research

Volume 1, Issue 2, September 2007, Pages 50 - 50

06.02 AORTIC AND CAROTID STIFFNESS IN OLDER ADULTS. THE ROTTERDAM STUDY

Authors
F.U.S. Mattace-Raso1, N.M. van Popele2, A. Hofman2, J.C.M. Witteman2
1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands
2Department of Epidemiology & Biostatistics, Erasmus University Medical Center, Rotterdam, Netherlands
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.047How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

The purpose of this study is to describe aortic (aPWV) and carotid stiffness (DC) in older adults according to age, gender and blood pressure. Information on both measures was available for 2766 subjects. The mean value of both aPWV and DC was lower in women than in men. The difference (95% CI) in aPWV was −0.99 (−0.81 to −1.18) (m/s) and the difference in DC was −1.62 (−1.35 to −1.82) (10−3/kPa) for women as compared for men. With aging, both aorta and carotid artery become stiffer but the increase attenuates at high age. Women under 80 years of age had a less stiff aorta and a stiffer common carotid artery as compared to men of the same age. The relations of both measures of arterial stiffness with SBP and PP were non-linear, flattening off at higher levels, whereas the relation with DBP was non-linear and resembled a J-shape. We found a quadratic relationship between DC and aPWV: DC = 27.4 − 1.9 (aPWV) + 0.04 ∗ (aPWV)2 [p total model ≤ 0.001], (R2= −0.41, P<0.001). Subjects with increased aortic stiffness had a 30-fold increased risk of also having increased carotid stiffness, OR 31.2 (95% CI 20.9−46.4) (Figure 1).

Figure 1

Mean (95% CI) aPWV and DC per 5-years age category in strata of gender. *p < 0.05 for difference between men and women.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
50 - 50
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.047How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - F.U.S. Mattace-Raso
AU  - N.M. van Popele
AU  - A. Hofman
AU  - J.C.M. Witteman
PY  - 2007
DA  - 2007/08/30
TI  - 06.02 AORTIC AND CAROTID STIFFNESS IN OLDER ADULTS. THE ROTTERDAM STUDY
JO  - Artery Research
SP  - 50
EP  - 50
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.047
DO  - 10.1016/j.artres.2007.07.047
ID  - Mattace-Raso2007
ER  -