Artery Research

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Volume 6, Issue 4, December 2012, Pages 184 - 184

P4.05 AN EXAMINATION OF THE CARDIAC MECHANICS AND PULSE PRESSURE WAVEFORMS THAT UNDERPIN VENTRICULAR-ARTERIAL INTERACTION AT REST AND DURING EXERCISE

Authors
M. Kearney1, K. Stone1, E. Stohr1, J. Thompson1, Z. Yousef3, J. Cockcroft2, R. Shave1, K. Backx1
1Cardiff Metropolitan University, Cardiff, United Kingdom
2Wales Heart Research Institute, Cardiff University, Cardiff, United Kingdom
3University Hospital Wales, Cardiff, United Kingdom
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.153How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: In healthy humans the left ventricle (LV) and the arterial system reciprocally interact to meet the circulatory demands of the body both at rest and during exercise. Ventricular-arterial interaction (VAI) can be quantified non-invasively using the ratio of arterial (Ea) and ventricular (Ees) elastances. However, Ees is a global measure of LV systolic function and Ea does not take into account the effect of wave reflections. Speckle tracking echocardiography (STE) and pulse wave analysis (PWA) allow for regional quantification of both cardiac and vascular functioning throughout the cardiac cycle. The purpose of this study was to characterise VAI using STE and PWA to explore the LV mechanics e.g. LV twist, and components of the pulse pressure waveform e.g. augmentation index (AIx), that underpin VAI at rest and during exercise.

Methods: 9 (7 male) healthy participants (43±7 years) underwent simultaneous STE and PWA at rest and during exercise.

Results: During exercise there was a decrease in Ea/Ees due to significant changes in Ees but not Ea. Whilst there were no significant changes in Ea during exercise both AIx and time to forward wave were significantly reduced. In contrast, the alteration in Ees was paralleled by significant changes in peak twist, time to peak twist, untwisting velocity and apical rotation.

Conclusions: The combined use of STE and PWA appears more sensitive to acute physiological changes induced by exercise than the classic VAI ratio: Ea/Ees. Future work will examine the sensitivity of combining STE and PWA to unmask subclinical cardiovascular pathology.

Variable Rest: mean (SD) Exercise: mean (SD)
Ea (mmHg/ml) 2.12 (0.56) 2.07 (0.56)
Ees (mmHg/ml) 2.92(1.13) 3.53 (1.25)*
Ea/Ees (mmHg/ml) 0.77 (0.22) 0.61(0.12)*
AIx (%) 12.67 (8.71) 5.44 (8.57)**
Time to forward wave (ms) 113.11 (10.3) 100.67 (14.97)*
Peak twist (°) 8.88 (2.99) 15.29 (5.27)*
Time to peak twist (ms) 387.54 (55.54) 307.08 (24.46)*
Untwisting velocity (°/sec-1) −60.63 (13.30) −128.13 (44.45)*
Apical rotation (°) 6.66 (3.65) 11.30 (5.52)*
*

p<0.05;

**

p<0.001.

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Journal
Artery Research
Volume-Issue
6 - 4
Pages
184 - 184
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.153How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M. Kearney
AU  - K. Stone
AU  - E. Stohr
AU  - J. Thompson
AU  - Z. Yousef
AU  - J. Cockcroft
AU  - R. Shave
AU  - K. Backx
PY  - 2012
DA  - 2012/11/17
TI  - P4.05 AN EXAMINATION OF THE CARDIAC MECHANICS AND PULSE PRESSURE WAVEFORMS THAT UNDERPIN VENTRICULAR-ARTERIAL INTERACTION AT REST AND DURING EXERCISE
JO  - Artery Research
SP  - 184
EP  - 184
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.153
DO  - 10.1016/j.artres.2012.09.153
ID  - Kearney2012
ER  -