P2.33 PERIPHERAL VERSUS CENTRAL PULSE PRESSURE VALUES IN CALCULATIONS OF CAROTID DISTENSIBILITY AND COMPLIANCE

O. Mac Ananey; V. Maher

doi:10.1016/j.artres.2012.09.113

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 6, Issue 4, December 2012, Pages 173 - 173

P2.33 PERIPHERAL VERSUS CENTRAL PULSE PRESSURE VALUES IN CALCULATIONS OF CAROTID DISTENSIBILITY AND COMPLIANCE

Authors

O. Mac Ananey, V. Maher

Adelaide & Meath Hospital incorporating the National Children’s Hospital, Dublin, Ireland

Available Online 17 November 2012.

DOI: 10.1016/j.artres.2012.09.113 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

The aim of our study was to compare carotid compliance and distensibility calculations derived from central aortic pressure and peripheral brachial blood pressure measurements.

For this study 232 healthy, lifelong non-smoking, normotensive subjects (111 male & 121 female) were recruited (age 40±11 years, BMI 25.7±4.1 kg.m²). Augmentation index (AIx), central aortic pressure (Sphygmacor, Skidmore Medical, UK), pulse wave velocity (PWV; Vicorder, Skidmore Medical, UK) and brachial blood pressure (Dynamap Pro, GE, USA), were measured using applanation tonometry. Stroke changes in common carotid diameter and intima-media thickness (CIMT) were measured from ultrasound (Philips HDX7E, Philips, UK) images using semi-automated software¹ (QLAB, Philips, UK). Carotid compliance and distensibility were subsequently calculated using brachial and aortic pulse pressure values.

Mean AIx, PWV and CIMT was 16.45±14.79 %, 7.04±1.22 m.s⁻¹ and 0.52±0.07 mm respectively. Carotid distensibility & compliance values calculated using brachial blood pressure (35.08±22.25 kPa.10⁻³ & 11.23±7.95 m².kPa.10⁻⁷) were significantly (p<0.001) lower compared to aortic derived measurements (48.63±34.81 kPa.10⁻³ & 15.68±13.09 m².kPa.10⁻⁷). Spearman’s analysis showed that aortic derived calculations of compliance & distensibility were more strongly correlated with indices of arterial stiffness compared to brachial derived calculations (Table 1).

	Brachial		Aortic

	Distensibility	Compliance	Distensibility	Compliance

	r	r	r	r
PWV	−0.0308	−0.0367	−0.3028^**	−0.2674^**
AIx	0.0843	−0.0452	−0.4298***	−0.5250^***
CIMT	−0.0598	0.0741	−0.2327^*	−0.1430

*

p<0.05,

**

p<0.01,

***

p<0.001.

Table 1

Spearman’s correlation analysis between brachial/aortic pulse pressure derived distensibility/compliance measurements.

The results of the study reveal important considerations for blood pressure derived calculations of arterial stiffness.

1.Y Eric et al., Carotid Arterial Wall Characteristics Are Associated With Incident Ischemic Stroke But Not Coronary Heart Disease in the Atherosclerosis Risk in Communities (ARIC) Study, Stroke, Vol. 43, 2012, pp. 103-108.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 6 - 4
Pages: 173 - 173
Publication Date: 2012/11/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.09.113 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - O. Mac Ananey
AU  - V. Maher
PY  - 2012
DA  - 2012/11/17
TI  - P2.33 PERIPHERAL VERSUS CENTRAL PULSE PRESSURE VALUES IN CALCULATIONS OF CAROTID DISTENSIBILITY AND COMPLIANCE
JO  - Artery Research
SP  - 173
EP  - 173
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.113
DO  - 10.1016/j.artres.2012.09.113
ID  - Ananey2012
ER  -

download .riscopy to clipboard