Artery Research

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Volume 6, Issue 4, December 2012, Pages 171 - 171

P2.27 LOCAL RADIAL STRAIN OF THE COMMON CAROTID ARTERY WALL

Authors
E. Hermeling1, 4, F.H. Schreuder2, W.H. Mess2, M.E. Kooi1, 4, A.P.G. Hoeks3, 4
1Department of Radiology, Maastricht University Medical Centre, Maastricht, Netherlands
2Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, Netherlands
3Department of Biomedical Engineering, Maastricht University, Maastricht, Netherlands
4Cardiovascular Research Institute Maastricht, Maastricht, Netherlands
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.108How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Rupture of atherosclerotic plaques occurs when mechanical stress exceeds material strength. Increased radial strain (ϵ, measured in the wall tissue) may be indicative for both locally increased mechanical stress as well as locally decreased material strength. The aim of our feasibility study was to analyse the precision and accuracy of ϵ, within the common carotid artery (CCA) wall of patients with and without recent cerebrovascular accident (CVA,<6weeks).

Methods: The left and right CCA of 21 patients (15 with CVA) were measured twice with multiple M-mode ultrasound. ϵ was determined for the intima-media layer (ϵm) and adventitia layer (ϵa), separately, using an RF-based algorithm. Intima-to-intima ((ΔD/D)in) and adventitia-to-adventitia relative distension ((ΔD/D)out) were also obtained, which are strongly related to strain (ϵ ≈−ΔD/D) when wall-inhomogeneities are negligible.

Results: Intra-subject precision was 1.8% for ϵm and 1.0% for ϵa. Averaged over all patients, ϵm=−7.4±2.7% (mean±sd) was higher than ϵa=−3.9±1.7% (p<0.0001). ϵm was significantly correlated with (ΔD/D)in (r2=0.48, p<0.0001), but higher than −(ΔD/D)in (Δ=0.8±2.1%,p=0.02). For the adventitial layer, the correlation between ϵa and (ΔD/D)out was weaker (r2=0.10,p=0.05; Δ=0.7±2.0%,p=0.02). Despite similar blood pressures and stenosis degrees, ϵm, (ΔD/D)out, (ΔD/D)in, but not ϵa, were higher at the ipsilateral side for patients with than for patients without CVA, (p=0.002,p=0.05 and p=0.06, respectively).

Conclusion: Strain can be measured directly within wall tissue with reasonable accuracy and precision and allows discrimination between arterial layers and patient groups. As ΔD/D is not applicable to inhomogeneous walls, strain is a promising tool to evaluate vulnerability of plaques.

N# SBP(mmHg) DBP(mmHg) stenosis degree(%) ϵm(%) ϵa(%) (ΔD/D)in (%) (ΔD/D)out (%)
ipsilateral 14 136±22 77±12 38±36 −8.5±2.5* −4.3±1.3 7.2±2.9 5.1±2.0*
contralat. 15 28±33 −7.8±2.6* −3.8±1.2 7.1±2.7 4.9±1.6
w/o CVA 10 145±18 85±10 27±29 −5.3±1.8 −3.5±2.5 5.1±2.1 3.6±1.4
*

significant different from patient without (w/o) CVA using Student t-test; number of CCAs (N); systolic blood pressure (SBP); diastolic blood pressure (DBP); contralat, contralateral.

#

1 ipsilateral CCA of patients with CVA and 2 CCAs in patients without CVA were excluded due to poor image quality.

Table

Radial strain and relative distension between patients with and without CVA

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Journal
Artery Research
Volume-Issue
6 - 4
Pages
171 - 171
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.108How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - E. Hermeling
AU  - F.H. Schreuder
AU  - W.H. Mess
AU  - M.E. Kooi
AU  - A.P.G. Hoeks
PY  - 2012
DA  - 2012/11/17
TI  - P2.27 LOCAL RADIAL STRAIN OF THE COMMON CAROTID ARTERY WALL
JO  - Artery Research
SP  - 171
EP  - 171
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.108
DO  - 10.1016/j.artres.2012.09.108
ID  - Hermeling2012
ER  -