Artery Research

Volume 6, Issue 4, December 2012, Pages 161 - 161

P1.37 RISK FACTORS FOR INTIMAL HYPERPLASIA DEVELOPMENT AFTER CAROTID ENDARTERECTOMY

Authors
Elena Surkova, Olga Tereshina
Samara Medical State University, Samara, Russian Federation
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.074How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Intimal hyperplasia is a common complication occurring after carotid endarterectomy (CEA), although pathological mechanisms leading to its progression are not totally clear.

Methods: In our study we assessed a role of various factors including age, gender, hypertension, history of smoking, hyperlipidaemia, diabetes mellitus, lesions characteristics, type of arteriotomy closure and regional flow dynamics affecting intima-media thickness (IMT) past CEA. We examined 1003 patients prior to and 1 year after carotid endarterectomy using standardized duplex ultrasound examination. The median age of patients was 60±15 years. Univariate and multivariate regression analysis was used to identify major risk factors and possible correlations between them.

Results: Only 2 of systemic factors - elevated level of low-density lipoprotein and platelet aggregation were found to have a minor (although statistically significant) effect on IMT after CEA. Age, gender, hypertension, smoking were not significantly associated with the development of intimal hyperplasia past CEA. Complicated plaques showed a significant correlation with intimal hyperplasia. There were no significant differences in IMT between patients who have had eversion CEA versus CEA with patch.. Of local factors, only sheer stress demonstrated a negative correlation with IMT.

Conclusions: Our results demonstrate that multiple risk factors could be involved in the development of intimal thickening after CEA.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
161 - 161
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.074How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Elena Surkova
AU  - Olga Tereshina
PY  - 2012
DA  - 2012/11/17
TI  - P1.37 RISK FACTORS FOR INTIMAL HYPERPLASIA DEVELOPMENT AFTER CAROTID ENDARTERECTOMY
JO  - Artery Research
SP  - 161
EP  - 161
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.074
DO  - 10.1016/j.artres.2012.09.074
ID  - Surkova2012
ER  -