P1.15 ASSESSING THE CORRELATES OF ARTERIAL STRUCTURE AND FUNCTION IN HEALTHY ADOLESCENTS
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- 10.1016/j.artres.2012.09.052How to use a DOI?
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Background: Abnormal measures of arterial structure and function are increasingly used in adolescent disease populations to predict cardiovascular risk. Limited information is available in healthy adolescents of the correlates of these measures when obtained by different non-invasive methods on the same occasion.
Methods: In 113 healthy adolescents (57 females, aged 10–18 years), carotid intima-media thickness (CIMT), flow-mediated dilatation (FMD), aortic pulse wave velocity (PWV) by applanation tonometry, central PWV by echo-Doppler and distension coefficients of the ascending aorta (DCaao) and common carotid artery (DCcca) were measured. Sample characteristics were assessed against a standard normal distribution. Relationships were tested with gender, age, body surface area (BSA), brachial systolic blood pressure (SBP) and heart rate (HR) using Pearson’s correlations. Statistical significance was considered at p<0.05. Reproducibility studies (n=20), for intra-, inter-observer and test-retest coefficients of variation were respectively for CIMT 3.0, 7.4 and 4.6%, FMD baseline 1.4, 2.9 and 5.1%, and PWV 5.1, 6.0 and 8.8%.
Results: All vascular measures were normally distributed. Significant positive correlations (see Table) were found for: CIMT with BSA; aortic PWV with age, BSA and SBP; central PWV with age, BSA, HR and SBP; and DCaao with male gender. Significant negative correlations were found for: FMD with SBP; and DCaao and DCcca with age and BSA.
Conclusions: This normative dataset can now be used to determine abnormal arterial structure and function in adolescent disease populations. Of these vascular measures, aortic PWV appears to be the most dependent on increasing age, BSA, and SBP during adolescence.
| Variable Mean±SD | CIMT 0.431±0.046 mm | FMD 7.4±3.1 % | Aortic PWV 5.0±0.9 m/s | Central PWV 4.5±1.1 m/s | DCaao351±113 10−3 mmHg−1 | DCcca 439±107 10−3 mmHg−1 |
| Gender 57F:56M | r=−0.03, p=0.73 | r=+0.17, p=0.09 | r=+0.07, p=0.46 | r=−0.09, p=0.35 | r=+0.22, p=0.02 | r=+0.10, p=0.29 |
| Age 14.4±2.1 yrs | r=+0.07, p=0.49 | r=−0.08, p=0.43 | r=+0.51, p<0.001 | r=+0.22, p=0.02 | r=−0.28, p<0.001 | r=−0.34, p<0.001 |
| BSA 1.58±0.25 m2 | r=+0.25, p<0.01 | r=−0.04, p=0.69 | r=+0.45, p<0.001 | r=+0.32, p<0.001 | r=−0.31, p<0.001 | r=−0.32, p<0.001 |
| HR 69±13 bpm | r=+0.11, p=0.27 | r=+0.03, p=0.77 | r=+0.16, p=0.11 | r=+0.24, p=0.01 | r=−0.06, p=0.54 | r=−0.08, p=0.31 |
| SBP 109±10 mmHg | r=+0.14, p=0.15 | r=−0.20, p=0.04 | r=+0.36, p<0.001 | r=+0.23, p=0.02 | - | - |
Cite this article
TY - JOUR AU - T.J. Bradley AU - C. Slorach AU - C. Manlhiot AU - W. Hui AU - T. Sarkola AU - E.T. Jaeggi AU - L. Mertens PY - 2012 DA - 2012/11/17 TI - P1.15 ASSESSING THE CORRELATES OF ARTERIAL STRUCTURE AND FUNCTION IN HEALTHY ADOLESCENTS JO - Artery Research SP - 155 EP - 155 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.052 DO - 10.1016/j.artres.2012.09.052 ID - Bradley2012 ER -