P1.23 CENTRAL AORTIC PRESSURE AND ARTERIAL STIFFNESS PATTERNS ACCORDING TO DRUGS AND GENDER IN HYPERTENSIVE PATIENTS
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- 10.1016/j.artres.2012.09.060How to use a DOI?
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Background: Previously we described differences in central pressures and arterial stiffening according to gender and age, which are related to increased risk in elder women (W) and different responses to treatment.
Objectives: To study different arterial stiffness patterns in essential hypertensives (H) according to gender and different antihypertensives.
Methods: We included 564 H from JAN2007 to DIC2010. Inclusion criteria: age >40 and <70,at least 2 CV risk factors and 6 mo.under stable monotherapy with atenolol (ATEN)n:114, amlodipine (AML)n:113, enalapril: (ENL)n:195 or losartan (LOS)n:142. A Control group (C) was also included (131p). All with a rate males/women (M/W) 2/1. Evaluations: BP, cIMT, Plaques, cf PWV, Endothelial Function (EF), Central/Peripheral Pulse Pressure (PPc/PPp) and Augmentation Indexes (Aix c /Aix p).(Hemodyn 4/Arteriograph ®). Statistics: t test, ANOVA, Dunnet p <0,05.
Results: (only signif.) Peripheral BP, PP and PWV were higher in H than C. PPc and Aix c were higher in H than in C and in W than in M in every group. Aix p in H, were higher and positive in W and lower and negative in M. PWV was higher in M than W only in H. (table attached)
Conclusion: According to PP and Aix, two patterns: In M a“central stiffness pattern” with lower PPc than PPp, negative Aix p and higher PWV.
In W a“peripheral stiffness pattern” with higher PPc, positive Aix p and lower PWV. This last pattern could be related with the increased risk in elder W and was not corrected by treatment.
| Parameters | CONTROLS | ATEN | AML | ENL | LOS | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| GENDER | M (89) | F (42) | M (75) | F (39) | M (66) | F 47) | M (135) | F (60) | M (95) | F (47) |
| AGE | 49 ± 7 | 47,5± 7 | 56 ± 8 | 56 ± 8 | 55 ± 8 | 54 ± 9 | 55 ± 8 | 56 ± 8 | 57 ± 8 | 55 ± 7 |
| SBP mmHg | 127 ± 14 | 118,5 ± 14 | 131 ± 14 | 131 ± 12 | 136 ± 12 | 133 ± 11 | 135 ± 13 | 132 ± 12 | 131 ± 12 | 133 ± 12 |
| DBP mmHg | 80 ± 10 | 75 ± 9 | 83 ± 9 | 81 ± 8 | 84 ± 8 | 80 ± 10 | 84 ± 7,5 | 81 ± 8 | 83 ± 7,5 | 82 ± 8 |
| HR lpm | 63 ± 12 | 71 ± 11 | 61 ± 11 | 62 ± 7 | 66 ± 10 | 68 ± 12 | 67 ± 15 | 69 ± 11 | 66 ± 11 | 67 ± 12 |
| PP c mmHg | 37 ± 8 | 43 ± 9 | 48 ± 11 | 56 ± 10 | 48 ± 14 | 51 ± 12 | 47 ± 12 | 52 ± 11 | 46 ± 14 | 55 ± 9 |
| PP p mmHg | 47 ± 8 | 43 ± 10 | 48 ± 10 | 50 ± 9 | 51,5 ± 9 | 52,5 ± 15 | 51 ± 10 | 51 ± 10 | 48 ± 10 | 51 ± 7,5 |
| Aix c % | 19 ± 9,5 | 31 ± 12 | 32 ± 11,5 | 43 ± 8 | 30 ± 12 | 41 ± 9 | 28 ± 14 | 38 ± 11 | 27 ± 11 | 41 ± 11 |
| Aix p % | −30 ± 26,5 | −7 ± 31 | 4 ± 3 | 24 ± 18 | −5 ± 28 | 19 ± 20 | −10 ± 36 | 18 ± 47 | −13 ± 26 | 16,5 ± 27,5 |
| PWV m/s | 9 ± 2 | 9 ± 2 | 12 ± 9,5 | 10 ± 3 | 12 ± 2 | 10 ± 2 | 12 ± 2 | 10 ± 2 | 11 ± 2 | 10 ± 2 |
Ref: SBP: Systolic Blood Pressure DBP: Diastolic Blood pressure HR: Heart Rate PPc: Central Pulse Pressure PPp: Peripheral Pulse Pressure Aix c: Central Augmentation Index Aix p: Peripheral Augmentation Index PWV: Pulse Wave Velocity.
Cite this article
TY - JOUR AU - P. Forcada AU - D. Olano AU - S. Obregon AU - S. Gonzalez AU - C. Castellaro AU - J. Chiabaut AU - F. Inserra AU - C. Kotliar PY - 2012 DA - 2012/11/17 TI - P1.23 CENTRAL AORTIC PRESSURE AND ARTERIAL STIFFNESS PATTERNS ACCORDING TO DRUGS AND GENDER IN HYPERTENSIVE PATIENTS JO - Artery Research SP - 157 EP - 157 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.060 DO - 10.1016/j.artres.2012.09.060 ID - Forcada2012 ER -