1.5 BLOOD PRESSURE-INDEPENDENT ASSOCIATION BETWEEN AORTIC CHARACTERISTIC IMPEDANCE AND LEFT VENTRICULAR MASS IN HYPERTENSION

G. Pucci; F. Battista; L. Settimi; B. Hametner; S. Wassertheurer; G. Schillaci

doi:10.1016/j.artres.2012.09.011

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Volume 6, Issue 4, December 2012, Pages 142 - 142

1.5 BLOOD PRESSURE-INDEPENDENT ASSOCIATION BETWEEN AORTIC CHARACTERISTIC IMPEDANCE AND LEFT VENTRICULAR MASS IN HYPERTENSION

Authors

G. Pucci¹, F. Battista¹, L. Settimi¹, B. Hametner², S. Wassertheurer², G. Schillaci¹

¹University of Perugia at Terni, Terni, Italy

²Austrian Institute of Technology, Vienna, Austria

Available Online 17 November 2012.

DOI: 10.1016/j.artres.2012.09.011 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: It is uncertain whether pressure/flow ratio in the proximal aorta, namely aortic characteristic impedance (Z_c), is related to left ventricular (LV) mass independently of blood pressure (BP) level.

Methods: 435 never-treated subjects with uncomplicated essential hypertension free from overt cardiovascular disease (men 62%, age 48±11 years, BP 148/92±16/10 mmHg) underwent M-mode echocardiography and 24-hour BP monitoring. Aortic waveform was obtained from tonometric radial waveform with a validated generalized transfer function (SphygmoCor). Aortic Z_c and forward (P_f) and backward (P_b) wave amplitudes were calculated from central waveform using an aortic blood flow model based on higher-order Windkessel theory (ArcSolver), [Weber T et al, Hypertension EPub May 14, 2012].

Results: Patients with LV hypertrophy (LV mass >51 g/m^2.7) had a higher brachial systolic BP (SBP 153±18 vs 146±15 mmHg, p<0.001), central systolic BP (142±18 vs 133±16 mmHg, p<0.001), aortic Z_c (0.235±0.08 vs 0.211±0.06 AU, p<0.001), P_f (31.7±9 vs 28.6±7 mmHg, p<0.001), and P_b (19.8±7 vs 18.1±5 mmHg, p=0.02), while reflection magnitude (P_b/P_f) did not differ (0.62±0.10 vs 0.63±0.10, p>0.3). After controlling for age, sex, and mean arterial pressure as a measure of distending pressure, LV mass index maintained an independent association with Z_c (partial r=0.14, p=0.002), while the association of either P_b or P_f with LV mass became no longer significant. In a multiple linear regression model, Z_c independently predicted LV mass index (β=0.116, p=0.005) along with age, mean arterial pressure, and body mass index.

Conclusion: Aortic characteristic impedance has a significant, pressure-independent relationship with LV mass in human hypertension.

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Journal: Artery Research
Volume-Issue: 6 - 4
Pages: 142 - 142
Publication Date: 2012/11/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.09.011 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - G. Pucci
AU  - F. Battista
AU  - L. Settimi
AU  - B. Hametner
AU  - S. Wassertheurer
AU  - G. Schillaci
PY  - 2012
DA  - 2012/11/17
TI  - 1.5 BLOOD PRESSURE-INDEPENDENT ASSOCIATION BETWEEN AORTIC CHARACTERISTIC IMPEDANCE AND LEFT VENTRICULAR MASS IN HYPERTENSION
JO  - Artery Research
SP  - 142
EP  - 142
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.011
DO  - 10.1016/j.artres.2012.09.011
ID  - Pucci2012
ER  -

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