To test whether vascular function is altered in normal pregnancy and preeclampsia (hypertension and proteinuria after the 20^th week of pregnancy), we performed a cross-sectional study comparing 15 preeclamptic women (PE) with 31 normotensive pregnant -11 pair matched for gestational age (MGA-NP) and 20 at term (T-NP)- and 20 non-pregnant women (HC). All subjects were matched for age and BMI (<27 Kg/m²). Women with obesity, diabetes, pre-existing arterial hypertension were excluded. Women with PE received antihypertensive drugs. Stiffness index (SI) and Reflection Index (RI) were obtained by digital volume pulse analysis using photoplethysmography. Mean arterial pressure (MAP), plasma creatinine and uric acid were higher in PE (p<0.001 vs. NP and HC), whereas heart rate (HR) was lower in PE (p<0.05 vs. NP). RI was higher in PE respect to NP (median [min-max] 66.5%[37–80]) vs. 51.5% [31–80]; p<0.001) whereas SI tended to increase in PE (7.6 m/sec [5.6 13.5]; MGA_NP 6.5 m/sec [5.4–8.7]; p=0.10). When normalized for MAP, both SI/MAP and RI/MAP were similar in PE and NP, whereas SI/HR and RI/HR normalized for HR were higher in PE (p<0.05 vs. NP and MGA_NP). SI (p<05) was higher in PE respect to HC. Correlation between SI and RI (r_s=0.56 p<0.001), MAP and both SI and RI (r_s=0.48 p=0.001; r_s=0.50 p<0.001), HR and RI (r_s=0.58 p<0.001), uric acid and RI (r_s=0.41 p=0.007) was observed in PE+NP. The present results confirm that vascular function is altered in PE with higher RI suggesting peripheral vasoconstriction and a tendency toward higher SI, suggesting diminished compliance.