Artery Research

Volume 4, Issue 4, December 2010, Pages 185 - 185

P13.07 SEVERITY OF VASCULAR DISEASE IN UNCONTROLLED HYPERTENSIVES: ARE TWO SIDES OF A COIN?

Authors
P. Forcada1, D. Olano2, S. Gpnzalez1, S. Obregon1, J. Chiabaut Svane1, E. Cavanagh2, F. Inserra2, C. Kotliar1
1Hospital Universitario Austral, Pilar, Argentina
2Universidad Austral, Pilar, Argentina
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.139How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: Uncontrolled blood pressure (UBP) is associated with higher risk of target organ damage and CV events. A severe subclinical impairment of vascular function and structure should be expected in this situation but, currently this has not been analyzed.

Objective: To determine the pattern of vascular damage in UBP p.

Methods: We screened 3277 p. derived for non-invasive vascular evaluation (NIVE) (Dec 2006/Dec 2009).After applying exclusion criteria (age >65; diabetes mellitus, secondary HTN, previous CV events/secondary prevention) 1503 hypertensives were included and classified according BP values as UBP (≥140/90 mm Hg) or controlled (CBP)(<140/90 mm Hg).(ESH 2007)

NIVE comprised: IMT; PWV and FMD; atherosclerotic plaque (AP) characterization; Aortic and Peripheral pulse pressure(CPP and PPP) and Augmentation indexes (CAix and PAix).

Results: UBP were 729 p.(47 y.o.; 63% males; 153/96 ± 14/8mm Hg, 69 ± 11 bpm) and CBP 774p. (48.9 years old; 70% males; 124/78 ± 8/6 mm Hg, 66 ± 10 bpm).

UBP patients showed: >IMT (LCC 0,71 ± 0,2 vs 0,68 ± 0,2mm),>PPP (57 ± 12 vs 46 ± 7 mmHg), >CPP (58 ± 16 vs 43 ± 12 mmHg), >PAix (0.9 ± 32 vs −11 ± 32 %) and PWV (11 ± 3 vs 10 ± 2 m/s)(p< 0.5 for all). CPP/ PPP relation was inverted in UBP group.

Conclusions: UBP was associated with moderate to severe subclinical vascular disease in this large population but it is not clear if UBP is rather a consequence than a cause of subclinical vascular disease.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
185 - 185
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.139How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - P. Forcada
AU  - D. Olano
AU  - S. Gpnzalez
AU  - S. Obregon
AU  - J. Chiabaut Svane
AU  - E. Cavanagh
AU  - F. Inserra
AU  - C. Kotliar
PY  - 2010
DA  - 2010/12/02
TI  - P13.07 SEVERITY OF VASCULAR DISEASE IN UNCONTROLLED HYPERTENSIVES: ARE TWO SIDES OF A COIN?
JO  - Artery Research
SP  - 185
EP  - 185
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.139
DO  - 10.1016/j.artres.2010.10.139
ID  - Forcada2010
ER  -