P13.07 SEVERITY OF VASCULAR DISEASE IN UNCONTROLLED HYPERTENSIVES: ARE TWO SIDES OF A COIN?
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Introduction: Uncontrolled blood pressure (UBP) is associated with higher risk of target organ damage and CV events. A severe subclinical impairment of vascular function and structure should be expected in this situation but, currently this has not been analyzed.
Objective: To determine the pattern of vascular damage in UBP p.
Methods: We screened 3277 p. derived for non-invasive vascular evaluation (NIVE) (Dec 2006/Dec 2009).After applying exclusion criteria (age >65; diabetes mellitus, secondary HTN, previous CV events/secondary prevention) 1503 hypertensives were included and classified according BP values as UBP (≥140/90 mm Hg) or controlled (CBP)(<140/90 mm Hg).(ESH 2007)
NIVE comprised: IMT; PWV and FMD; atherosclerotic plaque (AP) characterization; Aortic and Peripheral pulse pressure(CPP and PPP) and Augmentation indexes (CAix and PAix).
Results: UBP were 729 p.(47 y.o.; 63% males; 153/96 ± 14/8mm Hg, 69 ± 11 bpm) and CBP 774p. (48.9 years old; 70% males; 124/78 ± 8/6 mm Hg, 66 ± 10 bpm).
UBP patients showed: >IMT (LCC 0,71 ± 0,2 vs 0,68 ± 0,2mm),>PPP (57 ± 12 vs 46 ± 7 mmHg), >CPP (58 ± 16 vs 43 ± 12 mmHg), >PAix (0.9 ± 32 vs −11 ± 32 %) and PWV (11 ± 3 vs 10 ± 2 m/s)(p< 0.5 for all). CPP/ PPP relation was inverted in UBP group.
Conclusions: UBP was associated with moderate to severe subclinical vascular disease in this large population but it is not clear if UBP is rather a consequence than a cause of subclinical vascular disease.
Cite this article
TY - JOUR AU - P. Forcada AU - D. Olano AU - S. Gpnzalez AU - S. Obregon AU - J. Chiabaut Svane AU - E. Cavanagh AU - F. Inserra AU - C. Kotliar PY - 2010 DA - 2010/12/02 TI - P13.07 SEVERITY OF VASCULAR DISEASE IN UNCONTROLLED HYPERTENSIVES: ARE TWO SIDES OF A COIN? JO - Artery Research SP - 185 EP - 185 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.139 DO - 10.1016/j.artres.2010.10.139 ID - Forcada2010 ER -