Artery Research

Volume 4, Issue 4, December 2010, Pages 177 - 177

P10.06 RESPONSES OF THE AMBULATORY ARTERIAL STIFFNESS INDEX AND OTHER MEASURES OF ARTERIAL FUNCTION TO ANTIHYPERTENSIVE DRUGS

Authors
Y. Jin1, L. Thijs1, T. Richart1, 2, Y. Li3, E. Doland4, J.G. Wang3, A. Protogerou5, E. O’Brien6, J.A. Staessen1, 2, M.E. Safar7
1Univeristy of Leuven, Leuven, Belgium
2Maastricht University, Maastricht, Netherlands
3Shanghai Institute of Hypertension, Shanghai, China
4Addenbrooke’s hospital, Cambridge, United Kingdom
5National and Kapodistrian University of Athens, Athens, Greece
6University College Dublin, Dublin, Ireland
7Paris-Descartes University, Paris, France
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.109How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: We used antihypertensive drugs as pharmacologic tools to clarify the physiologic meaning of the ambulatory arterial stiffness index (AASI) in comparison to pulse pressures (PP), the arterio-ventricular coupling index (AVCI), and aortic pulse wave velocity (aPWV).

Methods: After a 4-week placebo period, 94 and 107 patients with uncomplicated hypertension were randomly assigned to treatment for one year with atenolol 50 mg/d (AT) or perindopril/indapamide 2/0.6 mg/d (PER/IND). From the individual readings in each patient’s 24‑hour ambulatory BP recording, we determined 24‑hour systolic and diastolic BP. We computed PP as the difference between 24‑hour systolic and diastolic BP, AASI as unity minus the regression slope of diastolic on systolic BP, and AVCI as (T/τ)/(1+2T/3τ)), where T is the heart period in seconds and τ is the decay time of aortic BP during diastole.

Results: Compared to PER/IND, in patients on AT, systolic BP and PP decreased less and AVCI lengthened more (P≤0.009), whereas the changes in AASI and aPWV did not differ between the two treatment groups (P≥0.25). In patients with the metabolic syndrome (NCEP-ATPIII criteria), AT and PER/IND lowered systolic BP similarly, but AT lowered diastolic BP more than PER/IND. Conversely, in patients without the metabolic syndrome, PER/IND lowered systolic BP more than AT, but diastolic BP to a similar extent.

Conclusions: On antihypertensive drugs with a different hemodynamic profile, AASI and aPWV behaved similarly. The metabolic syndrome seems to modulate the impact of antihypertensive drugs on systolic BP and PP.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
177 - 177
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.109How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Y. Jin
AU  - L. Thijs
AU  - T. Richart
AU  - Y. Li
AU  - E. Doland
AU  - J.G. Wang
AU  - A. Protogerou
AU  - E. O’Brien
AU  - J.A. Staessen
AU  - M.E. Safar
PY  - 2010
DA  - 2010/12/02
TI  - P10.06 RESPONSES OF THE AMBULATORY ARTERIAL STIFFNESS INDEX AND OTHER MEASURES OF ARTERIAL FUNCTION TO ANTIHYPERTENSIVE DRUGS
JO  - Artery Research
SP  - 177
EP  - 177
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.109
DO  - 10.1016/j.artres.2010.10.109
ID  - Jin2010
ER  -