Artery Research

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Volume 4, Issue 4, December 2010, Pages 179 - 180

P11.06 FIBRONECTIN, BUT NOT LAMININ CONTENT IS INCREASED IN THE TUNICA MEDIA OF SUBCUTANEOUS SMALL RESISTANCE ARTERIES OF PATIENTS WITH ESSENTIAL HYPERTENSION

Authors
C. De Ciuceis1, L.F. Rodella2, D. Rizzoni1, E. Porteri1, R. Rezzani2, G.E.M. Boari1, E. Borsani2, G. Favero2, C. Platto1, G.A.M. Tiberio3, S.M. Giulini3, E. Agabiti Rosei1
1Clinica Medica, Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
2Chair of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
3Clinica Chirurgica, Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.119How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: It was suggested that, in the development of hypertensive microvascular remodeling, a relevant role may be played by laminin and fibronectin vascular content Aim of this study was to evaluate the amount of fibronectin and laminin within the tunica media of subcutaneous small arteries of normotensive subjects and essential hypertensive patients.

Design and Methods: We have investigated 6 normotensive control subjects and 10 essential hypertensive patients. All subjects were submitted to a biopsy of subcutaneous fat from the gluteal or the anterior abdominal region. Subcutaneous small resistance arteries were dissected and mounted on an isometric myograph, and the tunica media to internal lumen ratio was measured. In addition, the fibronectin and laminin content within the tunica media was evaluated by immunohistochemistry, with image analysis (% of area stained).

Results: As expected, clinic blood pressure values and media to lumen ratio were higher in essential hypertensive patients than in normotensive controls. Fibronectin media content was significantly greater in essential hypertensive patients (7.41±2.28 %), compared with normotensive controls (5.62±0.40, P<0.05). A significant correlation was observed between fibronectin media content and media to lumen ratio (r=0.49, p<0.05). No significant difference in laminin media content was observed between groups (3.7±1.71 % in essential hypertensive patients, 5.63±1.79 % in normotensive controls).

Conclusions: Our results indicate that, in small resistance arteries of patients with essential hypertension, fibronectin, but not laminin media content is increased. Fibronectin might be therefore involved in the development of small resistance artery remodeling in humans.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
179 - 180
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.119How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C. De Ciuceis
AU  - L.F. Rodella
AU  - D. Rizzoni
AU  - E. Porteri
AU  - R. Rezzani
AU  - G.E.M. Boari
AU  - E. Borsani
AU  - G. Favero
AU  - C. Platto
AU  - G.A.M. Tiberio
AU  - S.M. Giulini
AU  - E. Agabiti Rosei
PY  - 2010
DA  - 2010/12/02
TI  - P11.06 FIBRONECTIN, BUT NOT LAMININ CONTENT IS INCREASED IN THE TUNICA MEDIA OF SUBCUTANEOUS SMALL RESISTANCE ARTERIES OF PATIENTS WITH ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 179
EP  - 180
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.119
DO  - 10.1016/j.artres.2010.10.119
ID  - DeCiuceis2010
ER  -