Artery Research

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Volume 4, Issue 4, December 2010, Pages 174 - 174

P9.06 SERUM URIC ACID LEVELS AND ARTERIAL STIFFNESS AND CARDIAC AND CAROTID ARTERY STRUCTURE IN A GENERAL POPULATION IN NORTHERN ITALY

Authors
M. Salvetti, M.L. Muiesan, A. Paini, C. Agabiti Rosei, C. Aggiusti, D. Stassaldi, F. Beschi, C. Monteduro, M. Castellano, E. Agabiti Rosei
Internal Medicine, University of Brescia, Italy
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.098How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: The relationship between serum uric acid (UA) levels and CV disease has been described since the late 19th century.The role of UA as an independent risk factor for CV events and its association with TOD is however less clear. Aim of the study was to assess the relationship between UA and TOD in a general population (Vobarno Study).

Methods: 385 subjects (age 56±9yrs, 44%males, 64% hypertensives, 32%treated) underwent laboratory examinations and clinic and 24 hours BP measurement.Left ventricular and carotid artery structure were assessed by ultrasound and carotid-femoral PWV was measured using Complior.

Results: Subjects with increased UA (>6 mg/dl in ♀ and >7 mg/dl in ♂) were older, had greater BMI, higher BP, glucose, cholesterol and triglycerides levels and lower HDL cholesterol and e-GFR.Subjects with increased UA had also increased PWV (11.1±4.1 vs 13.3±3.7m/sec,p<0.0001), and a slight increase in left ventricular mass index (LVMI) (38.7±10.6 vs 43.0±11gr/m2.7, p<0.05) and IMT (Meanmax 1.1±0.28 vs 1.2±0.29 mm, p<0.05).After adjusting for confounders, including e-GFR, in a multivariable model, PWV was significantly greater in subjects with increased UA (11.1±2.41 vs 13.4±3.7 m/sec, p<0.001), while no significant difference in LVMI and IMT was observed. A significant correlation between UA levels and PWV(r=0.279,p<0.001),LVMI(r=0.157,p<0.001),meanmax IMT(r=0.159,p<0.001) was observed. After adjusting for confounders, serum UA levels were independently correlated to PWV, but not to LVMI and IMT.

Conclusions: Subjects with increased UA have increased arterial stiffness, but comparable left ventricular anatomy and carotid artery structure. The increase in arterial stiffness might contribute to the higher CV risk in these subjects.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
174 - 174
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.098How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M. Salvetti
AU  - M.L. Muiesan
AU  - A. Paini
AU  - C. Agabiti Rosei
AU  - C. Aggiusti
AU  - D. Stassaldi
AU  - F. Beschi
AU  - C. Monteduro
AU  - M. Castellano
AU  - E. Agabiti Rosei
PY  - 2010
DA  - 2010/12/02
TI  - P9.06 SERUM URIC ACID LEVELS AND ARTERIAL STIFFNESS AND CARDIAC AND CAROTID ARTERY STRUCTURE IN A GENERAL POPULATION IN NORTHERN ITALY
JO  - Artery Research
SP  - 174
EP  - 174
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.098
DO  - 10.1016/j.artres.2010.10.098
ID  - Salvetti2010
ER  -