Artery Research

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Volume 4, Issue 4, December 2010, Pages 175 - 175

P9.10 IN THE ELDERLY, ENDOTHELIAL DYSFUNCTION AND LOW-GRADE INFLAMMATION DO NOT PLAY A PROMINENT ROLE IN LOCAL ARTERIAL STIFFENING – THE HOORN STUDY -

Authors
B.C.T. van Bussel1, 2, R.M.A. Henry1, 3, C.G. Schalkwijk1, 3, I. Ferreira1, 3, 4, 5, J.M. Dekker6, 7, G. Nijpels6, 8, C.D.A. Stehouwer1, 2, 3
1Dept. of Medicine MUMC+, Maastricht, Netherlands
2School for Nutrition, Toxicology and Metabolism (NUTRIM), MUMC+, Maastricht, Netherlands
3Cardiovascular Research Institute Maastricht (CARIM) MUMC+, Maastricht, Netherlands
4School for Public Health and Primary Care (CAPHRI), MUMC+, Maastricht, Netherlands
5Department of Clinical Epidemiology and Medical Technology Assessment MUMC+, Maastricht, Netherlands
6The Institute for Research in Extra-mural Medicine (EMGO), VUmc, Amsterdam, Netherlands
7Dept. of Epidemiology and Biostatistics, VUmc, Amsterdam, Netherlands
8Dept. of General Practice, VUmc, Amsterdam, Netherlands
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.102How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Purpose: To investigate, in the elderly, the association between plasma biomarkers of endothelial dysfunction (ED) and low-grade inflammation (LGI) on the one hand and greater local arterial stiffness of the carotid, femoral and brachial arteries on the other.

Methods: Plasma biomarkers for ED (vWf, sVCAM-1, sE-selectin, sICAM-1) and LGI (CRP, SAA, IL6, TNF-α, sICAM-1) were determined and combined into mean z-scores, in a cohort stratified by glucose tolerance status (GTS) (n=745; DM2=275, IGM=183, NGM=287; age 68.7±7.0 years). Ultrasonography was used to measure arterial properties and local arterial stiffness estimates were calculated: distensibility (DC) and compliance coefficients (CC), in all arteries, and the carotid Young’s elastic modulus (YEM). Linear regression analyses were used to investigate the above associations.

Results: The study population was characterized by a high prevalence of prior cardiovascular disease (CVD) (48%), hypertension (70%) and use of lipid-lowering (17%) and anti-hypertensive (39%) medication. After adjustment for sex, age, mean arterial pressure and GTS, ED was not associated with carotid, femoral or brachial stiffness (e.g. for the carotid artery (β(95%CI): DC: 0.19(−0.24;0.62), CC: −0.01(−0.03;0.02) and YEM: 0.03(−0.03;0.08)). LGI was not associated with carotid, femoral or brachial stiffness, except for YEM (0.07(0.02;0.12); other data not shown).

Discussion: In an elderly population at high CVD risk, ED and LGI were not associated with local arterial stiffness, except for LGI and YEM. This suggests that ED and LGI, as estimated by these markers, do not play a prominent role in arterial stiffening, as estimated by these local arterial stiffness estimates.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
175 - 175
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.102How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - B.C.T. van Bussel
AU  - R.M.A. Henry
AU  - C.G. Schalkwijk
AU  - I. Ferreira
AU  - J.M. Dekker
AU  - G. Nijpels
AU  - C.D.A. Stehouwer
PY  - 2010
DA  - 2010/12/02
TI  - P9.10 IN THE ELDERLY, ENDOTHELIAL DYSFUNCTION AND LOW-GRADE INFLAMMATION DO NOT PLAY A PROMINENT ROLE IN LOCAL ARTERIAL STIFFENING – THE HOORN STUDY -
JO  - Artery Research
SP  - 175
EP  - 175
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.102
DO  - 10.1016/j.artres.2010.10.102
ID  - vanBussel2010
ER  -