Artery Research

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Volume 4, Issue 4, December 2010, Pages 166 - 166

P6.03 EVOLUTION OF ARTERIAL STIFFNESS AFTER KIDNEY TRANSPLANTATION IN PATIENTS WITH END-STAGE RENAL DISEASE

Authors
C. Bachelet-Rousseau1, 3, A. Kearney-Schwartz2, 3, L. Frimat1, 3, M. Kessler1, 3, A. Benetos2, 3
1Department of Nephrology, Brabois Hospital, University of Nancy, Nancy, France
2Department of Geriatrics, Brabois Hospital, University of Nancy and INSERM U961, Nancy, France
3Center of Clinical Investigation, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Nancy, France
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.073How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Increased arterial stiffness (AS) is a major determinant of cardiovascular complications in end-stage renal disease (ESRD) patients. Little is known about AS evolution after renal transplantation. The aim of the study was to characterize the evolution of AS after renal transplantation in a population of ESRD patients, in comparison to those patients remaining in dialysis.

Material and methods: One hundred patients were recruited from the waiting list of the Transplant Unit of the University Hospital of Nancy. Two vascular evaluations were performed at one-year interval. AS was assessed by carotid/femoral pulse wave velocity (PWV). During this interval, thirty-nine patients were transplanted and forty-nine remained on dialysis.

Results: At baseline PWV value was 10.6 ± 3.7 m/s. No difference was found between the two groups at the first and second visit. Mean arterial pressure (MAP) decreased in the transplant group (101 ± 14 vs. 95 ± 10 mmHg, p <0.01 respectively) at one-year follow up. Multivariate analysis showed that PWV changes depended on changes in MAP and baseline PWV.

Conclusion: Although no difference in the one-year PWV evolution was found, the lower MAP value in the transplanted group could result in a better long term evolution of arterial stiffness in this group, leading to a better cardiovascular prognosis after renal transplantation.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
166 - 166
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.073How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C. Bachelet-Rousseau
AU  - A. Kearney-Schwartz
AU  - L. Frimat
AU  - M. Kessler
AU  - A. Benetos
PY  - 2010
DA  - 2010/12/02
TI  - P6.03 EVOLUTION OF ARTERIAL STIFFNESS AFTER KIDNEY TRANSPLANTATION IN PATIENTS WITH END-STAGE RENAL DISEASE
JO  - Artery Research
SP  - 166
EP  - 166
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.073
DO  - 10.1016/j.artres.2010.10.073
ID  - Bachelet-Rousseau2010
ER  -