P5.07 MAXIMUM-IMT, PLAQUE SCORE, PLAQUE NUMBER AND PERCENT AREA STENOSIS ARE HIGHER AMONG ADULT PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA THAN THEIR ADULT FIRST-DEGREE RELATIVES
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- 10.1016/j.artres.2010.10.069How to use a DOI?
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Backgrounds and aim: Familial hypercholesterolemia (FH) is associated with not only severe coronary-artery disease but with accelerated carotid atherosclerosis. We compared the severity of carotid atherosclerosis at adult patients with FH and their adult first-degree relatives using high-resolution ultrasound methods.
Subjects and methods: The study included 32 patients with FH (mean±SD age, 35,44±9,9 years) and 21 their first-degree relatives (32,24±11,22 years). All patient were not older than 53. The level of the total cholesterol and LDL-cholesterol was significantly higher among FH patients than their relatives (9,98±2,93 mmol/l vs 5,08±0,89 mmol/l, p<0,001 and 7,07±3,07 mmol/l vs 3,14±0.87 mmol/l, p<0,001 respectively). Carotid atherosclerosis was evaluated by the following indices: mean-IMT, maximum-IMT, plaque score, plaque number and percent area stenosis.
Results: Mean-IMT have not differed in groups. Maximum-IMT, plaque score, plaque number and percent area stenosis were significantly higher among FH patients than their relatives.
Conclusions: Carotid atherosclerosis in adult patients with familial hypercholesterolemia is more severe than in their adult first-degree relatives.
| Subjects (mean±SD) | First-degree relatives (n=21) | Patients with FH (n=32) | p value |
|---|---|---|---|
| Age, years | 32,24±11,22 | 35,44± 9,9 | 0,158 |
| Mean-IMT, mm | 0,577±0,125 | 0,635±0,183 | 0,349 |
| Maximum-IMT, mm | 0,757±0,193 | 0,988±0,348 | 0,006 |
| Plaque number | 1,1±1,9 | 3,2±2,6 | 0,0009 |
| Plaque score, mm | 1,57±3,1 | 5,14±4,97 | 0,001 |
| Percent area stenosis, % | 11,9±19,6 | 37,6±22,4 | 0,0004 |
Cite this article
TY - JOUR AU - A.I. Ershova AU - A.N. Meshkov AU - P.P. Malyshev AU - T.A. Rozhkova AU - T.V. Balakhonova AU - S.A. Boytsov PY - 2010 DA - 2010/12/02 TI - P5.07 MAXIMUM-IMT, PLAQUE SCORE, PLAQUE NUMBER AND PERCENT AREA STENOSIS ARE HIGHER AMONG ADULT PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA THAN THEIR ADULT FIRST-DEGREE RELATIVES JO - Artery Research SP - 165 EP - 165 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.069 DO - 10.1016/j.artres.2010.10.069 ID - Ershova2010 ER -