Objective: Central BP (cBP) stronger correlates with target organ damage than casual brachial BP. pportive data for superiority of cBP over ambulatory BP. The aim of the study was to evaluate correlation between left ventricular mass index (LVMI) and central, clinic and ambulatory BP in young men.

Methods: 196 male subjects 18–25 (21±1,4) years with a history of casual BP elevation underwent routine physical, laboratory and instrumental tests, ABPM and pulse wave analysis (Sphygmocor, AtCor, Australia). Arterial hypertension (AH) was considered sustained if both clinic BP and ABPM values exceeded recommended diagnostic thresholds. Observed/predicted LVM ratio (OPLVMR) was assessed using de Simone et al. approach. Spearman analysis was performed to assess correlation between LVMI and OPLVNR.

Results: 24-h and daytime SBP (r=0,30 and r=0,31, p<0,001) slightly stronger than clinic SBP (r=0,27, p<0,001) correlated with LVMI. Correlation between cPP and LVMI was r=0,26, p=<0,001. No significant correlation was found between clinic BP and OPLVMR. Stronger correlation with OPLVMR was observed for 24-h and daytime SBP (r=0, 32, p =0,001) than for cPP (r=0,25, p=0,01). In patients with sustained AH (n=114) no significant correlation between clinic BP, ABP or cPP and LVMI or OPLVMR was found but negative significant correlation was observed between PP amplification and LVMI (r=− 0,20, p=0,03) and positive with PP AIx r=0,21, p=0,02).

Conclusion: cBP seems not to be superior ABPM for LVMI and OPLVMR prediction. Correlations between PP amplification and AIx and LVMI in subjects with sustained AH may confirm impact of early changes of arterial stiffness for target organ damage in young hypertensive population.