P3.03 ARTERIAL STIFFNESS IS ASSOCIATED WITH A HIGHER RISK OF EXTEND PERIVENTRICULAR AND DEEP WHITE MATTER LESIONS ACCORDING TO GENDER IN ELDERLY

C. Collin; M. Revera; B. Mazoyer; S. Laurent; C. Tzourio; P. Boutouyrie; C. Dufouil

doi:10.1016/j.artres.2010.10.046

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Volume 4, Issue 4, December 2010, Pages 159 - 159

P3.03 ARTERIAL STIFFNESS IS ASSOCIATED WITH A HIGHER RISK OF EXTEND PERIVENTRICULAR AND DEEP WHITE MATTER LESIONS ACCORDING TO GENDER IN ELDERLY

Authors

C. Collin¹, M. Revera², B. Mazoyer³, S. Laurent¹, C. Tzourio⁴, P. Boutouyrie¹, C. Dufouil⁴

¹University Paris Descartes, Hôpital Européen Georges Pompidou and INSERM U970, Paris, France

²University of Milan-Bicocca and Istituto Auxologico Italiano, Milan, Italy

³University of Caen Basse-Normandie and CNRS-CEA UMR 6232, Caen, France

⁴University Pierre et Marie Curie Paris6, Hôpital Pitié-Salpetrière and Inserm U708, Paris, France

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.046 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

White matter lesions (WMLs) are detected on brain MRI of elderly and are predictive of cognitive decline. Arterial stiffness is a cause of systolic hypertension and of increase in central pressure and might predict cardiovascular events. This study aimed to examine relationships between arterial stiffness parameters and WMLs in a large noninstitutionalized French cohort.

Methods: In a sample of 931 subjects belonging to 3C-Dijon study, WMLs were detected using automated software from which total, periventricular and deep WMLs volumes were estimated. Central systolic blood pressure (SBP) and aortic stiffness (carotid-to-femoral Pulse Wave Velocity, PWV) were assessed by tonometry. Due to differences in vascular profile, analyses were stratified by gender.

Results: 349 males and 582 females (respectively 75.0±3.7 and 75.4±3.8yrs) were included. Males had higher cardiovascular risk factors: hypertension (69.3 vs. 61.5% for females, P<0.0005) and diabetes (11.8 vs. 5.5%, P<0.001). Mean Total WMLs were similar between males and females but PWV was higher in males (15.2±3.3 vs. 14.3±3.1 m/s). In multivariable analyses adjusted for age, brain volume, heart rate, hypertension and diabetes, PWV was related to higher periventricular WMLs volume only in males (odds ratio of being in 3^rd tertile of WML volume [per 1 SD increase in PWV]: 1.48; 95%CI: 1.10–2.02; P<0.05) but not in females. In contrast, in females, a higher central SBP was significantly associated with a greater volume of deep WMLs (OR: 1.27; P<0.05) but not in males.

Conclusion: These data suggest that relationships between aortic stiffness, central SBP and WMLs might differ by gender.

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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 159 - 159
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.046 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - C. Collin
AU  - M. Revera
AU  - B. Mazoyer
AU  - S. Laurent
AU  - C. Tzourio
AU  - P. Boutouyrie
AU  - C. Dufouil
PY  - 2010
DA  - 2010/12/02
TI  - P3.03 ARTERIAL STIFFNESS IS ASSOCIATED WITH A HIGHER RISK OF EXTEND PERIVENTRICULAR AND DEEP WHITE MATTER LESIONS ACCORDING TO GENDER IN ELDERLY
JO  - Artery Research
SP  - 159
EP  - 159
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.046
DO  - 10.1016/j.artres.2010.10.046
ID  - Collin2010
ER  -

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