8.6 PLASMA OSTEOPROTEGERIN AND PROTEINURIA ARE INDEPENDENTLY ASSOCIATED WITH HIGHLY SENSITIVE TROPONIN T IN CHRONIC KIDNEY DISEASE (CKD) STAGES 3 & 4

M.L. Ford; E.R. Smith; L.A. Tomlinson; C. Rajkumar; S.G. Holt

doi:10.1016/j.artres.2010.10.189

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Volume 4, Issue 4, December 2010, Pages 152 - 152

8.6 PLASMA OSTEOPROTEGERIN AND PROTEINURIA ARE INDEPENDENTLY ASSOCIATED WITH HIGHLY SENSITIVE TROPONIN T IN CHRONIC KIDNEY DISEASE (CKD) STAGES 3 & 4

Authors

M.L. Ford¹^{, *}, E.R. Smith², L.A. Tomlinson³, C. Rajkumar¹, S.G. Holt²

¹Brighton & Sussex Medical School, Brighton, United Kingdom

²Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom

³Clinical Pharmacology Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom

^*Corresponding author.

Corresponding Author

M.L. Ford

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.189 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Highly sensitive cardiac troponin-T (hs-cTropT) is a predictor of mortality in dialysis dependent renal failure patients. Vascular calcification is also associated with adverse outcome in CKD. Osteoprotegerin (OPG) is a mediator of the bone-vascular axis and has been associated with adverse cardiovascular outcomes.

Aims: We investigated the relationship of hs-cTrop T with OPG and other clinical and biochemical parameters in a cohort of patients with CKD stages 3 & 4.

Method: ELISA kits were used to measure hs-cTropT (Roche, UK) and OPG (Biovendor, CZ).

Results: 122 patients were studied, 95M:27F. Age 69±11 years (mean±SD). Diabetic:Non-Diabetic 28:94. Systolic BP 154±21mmHg, DBP 154±21mmHg, eGFR 32±11ml/min/1.73m², PO₄ 1.08±0.20mmol/l. uPCR^* 35.8 (14.9–75.2mg/mmol) (^*Geometric Mean (25^th–75^th centile), ^*iPTH 79.1 (49–127ng/l),^* OPG 9.41(7.4–12.1pmol/l), ^*hs-cTropT 0.174 (0.010–0.283μg/l).

Significant univariate correlation was found between hs-cTropT, Age, eGFR, uPCR, iPTH, OPG.

After stepwise multivariate analysis age (β=0.420, p < 0.001), loguPCR (β = 0.290, p < 0.001), eGFR (β = −0.281, p < 0.001) and logOPG (β=0.184, p=0.011) were independently associated with loghs-cTropT. Model adjusted R²=0.491. The other variables were excluded from the model.

Conclusion: In addition to the recognised cardiovascular risk factors age and eGFR, proteinuria and plasma osteoprotegerin are independently associated with hs-cTropT in CKD stages 3 & 4. This suggests involvement in the pathogenesis of cardiovascular disease in pre-dialysis CKD.

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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 152 - 152
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.189 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - M.L. Ford
AU  - E.R. Smith
AU  - L.A. Tomlinson
AU  - C. Rajkumar
AU  - S.G. Holt
PY  - 2010
DA  - 2010/12/02
TI  - 8.6 PLASMA OSTEOPROTEGERIN AND PROTEINURIA ARE INDEPENDENTLY ASSOCIATED WITH HIGHLY SENSITIVE TROPONIN T IN CHRONIC KIDNEY DISEASE (CKD) STAGES 3 & 4
JO  - Artery Research
SP  - 152
EP  - 152
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.189
DO  - 10.1016/j.artres.2010.10.189
ID  - Ford2010
ER  -

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