Artery Research

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Volume 4, Issue 4, December 2010, Pages 151 - 151

8.1 BLOOD PRESSURE INCREASE AND DEVELOPMENT OF TARGET ORGAN DAMAGE IN SUBJECTS WITH HIGH NORMAL BLOOD PRESSURE IN A GENERAL POPULATION SAMPLE. A 9 YEARS FOLLOW-UP

Authors
A. Paini*, M.L. Muiesan, M. Salvetti, C. Agabiti Rosei, C. Aggiusti, D. Stassaldi, F. Bertacchini, F. Beschi, M. Castellano, E. Agabiti Rosei
Internal Medicine, University of Brescia, Italy
*Corresponding author.
Corresponding Author
A. Paini
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.184How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Subjects with high-normal (HN) blood pressure (BP) may be at increased risk of progression to hypertension (HT) and of cardiovascular events, in comparison with normotensives (NT). Aim of our study was to evaluate the progression to hypertension and the development of target organ damage in a general population in Northern Italy.

Methods: In 585 subjects (age 50±8years, 46%males) a baseline visit and laboratory examinations were performed. Subjects were divided into 3 groups according to systolic (SBP) and diastolic blood pressure (DBP) values: NT (SBP/DBP<130/85 mmHg); HN(SBP/DBP>130/85 and <140/90 mmHg) and HT (SBP/DBP>140/90 mmHg).In 478 subjects a follow-up(FU) visit, laboratory examinations, measurement of carotid-femoral PWV and carotid IMT were performed after 8.7±2.3years.

Results: at baseline 30% of patients were NT, 25% were HN and 45% were HT. Among patients classified as HN at baseline, 71% developed hypertension at FU, 18% had HN BP, 11% were NT. Among subjects classified as NT at baseline, 34% developed hypertension at FU, 23 % were classified as HN and 43 % were NT. Mean BP values at FU were 129±13/82±7 in NT, 139±13/87±6 in HN, 146±15/89±8 mmHg in HT, respectively (ANOVA p<0.001). At FU in HN and in HT, as compared with NT, a significant increase of PWV (11.2±2.1 and 12.4±3.3 vs 10.1±1.9m/sec, ANOVA p<0.01) and of common carotid IMT(1.00±0.19 and 1.09±0.27 vs 0.93±0.15mm, ANOVA p<0.01) was observed.

Conclusions: In a general population in Northern Italy a large proportion of subjects with high normal BP developed hypertension and vascular target organ damage during a 9 years follow up.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
151 - 151
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.184How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A. Paini
AU  - M.L. Muiesan
AU  - M. Salvetti
AU  - C. Agabiti Rosei
AU  - C. Aggiusti
AU  - D. Stassaldi
AU  - F. Bertacchini
AU  - F. Beschi
AU  - M. Castellano
AU  - E. Agabiti Rosei
PY  - 2010
DA  - 2010/12/02
TI  - 8.1 BLOOD PRESSURE INCREASE AND DEVELOPMENT OF TARGET ORGAN DAMAGE IN SUBJECTS WITH HIGH NORMAL BLOOD PRESSURE IN A GENERAL POPULATION SAMPLE. A 9 YEARS FOLLOW-UP
JO  - Artery Research
SP  - 151
EP  - 151
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.184
DO  - 10.1016/j.artres.2010.10.184
ID  - Paini2010
ER  -