Artery Research

Volume 4, Issue 4, December 2010, Pages 145 - 145

1.4 CAN AIX PREDICT ALL-CAUSE MORTALITY IN A GENERAL POPULATION?

Authors
J.H. Janner1, *, J. Vestbo1, 2, E. Prescott3, 4
1Department of Cardiology and Respiratory Medicine, Hvidovre University Hospital, Copenhagen, Denmark
2Respiratory Research Group, School of Translational Medicine, The University of Manchester, Manchester, United Kingdom
3Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark
4The Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, Denmark
*Corresponding author.
Corresponding Author
J.H. Janner
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.030How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Aortic augmentation Index (AIx) is a measurement of pulse wave reflections and an indirect measure of arterial stiffness. AIx predicts all-cause mortality and CV-mortality in selected patient group with end-stage renal failure and in patients undergoing percutaneous coronary intervention (PCI). The objective of this study was to analyse AIx as an independent predictor of all-cause mortality in a population without known cardiovascular disease (CVD).

Methods: This study is based on 3,432 subjects from the 4th survey of the Copenhagen City Heart Study with AIx measured non-invasively. During follow-up (mean 6.5 years) 334 persons died. AIx was divided in tertiles with the lowest tertile as reference. Mortality risk was analyzed by Cox proportional hazard models with age as the underlying time scale adjusting for heart rate, height, weight, blood pressure, total-cholesterol, smoking, alcohol, diabetes, education, physical activity and predisposition to CVD.

Results: AIx significantly predicted all-cause mortality but in opposite direction for men and women.

Men Women


HR 95 % CI HR 95 % CI
AIx – intermediate vs. low tertile 1.86 1.06–3.27 0.66 0.44–0.99
AIx – high vs. low tertile 2.30 1.24–4.24 0.53 0.34–0.82

Conclusion: High AIx was associated with increased mortality in men but decreased in women. The surprising finding in women may be related to gender related difference in the arterial properties measured by AIx as also reflected by AIx reaching a plateau in women approximately ten years earlier than men.

Conclusion: High AIx increased the risk of mortality in men but the opposite was seen in women. This can be explained by a curvilinear AIx/age relationship more pronounced in women where old women may have decreased pulse wave reflections in accordance with findings in the Framingham studies.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
145 - 145
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.030How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J.H. Janner
AU  - J. Vestbo
AU  - E. Prescott
PY  - 2010
DA  - 2010/12/02
TI  - 1.4 CAN AIX PREDICT ALL-CAUSE MORTALITY IN A GENERAL POPULATION?
JO  - Artery Research
SP  - 145
EP  - 145
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.030
DO  - 10.1016/j.artres.2010.10.030
ID  - Janner2010
ER  -